Association between KIR Gene Polymorphism and Diabetes After Liver Transplantation

Fang Liu; Lei Han; Xibing Zhang

doi:10.47297/taposatWSP2633-456910.20220306

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Association between KIR Gene Polymorphism and Diabetes After Liver Transplantation

Volume 3, Issue 6

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Association between KIR Gene Polymorphism and Diabetes After Liver Transplantation
Association between KIR Gene Polymorphism and Diabetes After Liver Transplantation
The Affiliated Calmette Hospital of Kunming Medical University
Vol. 3, Issue 6, Pages: 66-69(2022)
Published： 25 June 2022 ，
DOI：10.47297/taposatWSP2633-456910.20220306
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Liu Fang,Han Lei,Zhang Xibing.Association between KIR Gene Polymorphism and Diabetes After Liver Transplantation[J].Theory and Practice of Science and Technology,2022,03(06):66-69.
DOI：

Liu Fang,Han Lei,Zhang Xibing.Association between KIR Gene Polymorphism and Diabetes After Liver Transplantation[J].Theory and Practice of Science and Technology,2022,03(06):66-69. DOI： 10.47297/taposatWSP2633-456910.20220306.

摘要

Abstract

One of the most frequent problems following liver transplantation is post-transplantation diabetes mellitus (PTDM)

which has a significant negative impact on the medium- and long-term quality of life of liver transplant recipients. A significant risk factor for the incidence and progression of PTDM is genetics. Killer cell immunoglobulin-like receptors (KIR) are expressed on the surface of NK cells and T cells and are members of the immunoglobulin superfamily. By identifying the appropriate ligand molecules on the surface of target cells

KIR controls the activity of NK cells and T cells. It influences Type 2 Diabetes Mellitus' (T2DM) onset and development. KIR gene polymorphism is related with T2DM

and the etiology of PTDM is comparable to that of T2DM. As a result

it may offer novel approaches to the prevention and management of diabetes following liver transplantation.

关键词

Keywords

Gene polymorphismKIR genotype

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