In the context of the “Yangtze River Delta Integration Strategy” being upgraded to a national strategy

it is important to examine the influencing factors of advanced structure of the manufacturing industry in the Yangtze River Delta region. This paper intends to select provincial panel data from 2005 to 2018 in the Yangtze River Delta region

screens out 11 influencing factors through literature review

and uses grey correlation and dynamic equation models to analyze the major influencing factors on advanced structure of the manufacturing industry. The results show that: (1) Among the 11 influencing factors

fixed asset investment has the highest correlation with advanced structure of the manufacturing industry

followed by opening up and human capital level. (2) The level of human capital significantly promotes the advanced industrial structure

and the impact of both fixed asset investment and opening up on the advanced structure of the manufacturing industry presents “inverted U-shaped”. According to the research results

it is suggested that the development of manufacturing structure in the Yangtze River Delta must optimize capital investment structure

and obtain high-quality labor force and high-end opening-up.