The Diagnostic and Prognostic Value of Transient Elastography in Primary Biliary Cholangitis

Rui Zhang; Lina Cui; Dawei Ding; Ying Han

doi:10.47297/taposatWSP2633-456915.20250612

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The Diagnostic and Prognostic Value of Transient Elastography in Primary Biliary Cholangitis

Volume 6, Issue 12

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The Diagnostic and Prognostic Value of Transient Elastography in Primary Biliary Cholangitis
The Diagnostic and Prognostic Value of Transient Elastography in Primary Biliary Cholangitis
1.Xi'an Medical University, Xi'an, Shaanxi, 710021, China
2.State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, National Clinical Research Center for Digestive Diseases, Xijing Hospital of Digestive Diseases, The Air Force Military Medical University, Xi'an, Shaanxi, 710032, China
Vol. 6, Issue 12, Pages: 72-74(2025)
Published：30 December 2025
DOI：10.47297/taposatWSP2633-456915.20250612
Accepted：

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Zhang Rui,Cui Lina,Ding Dawei,et al.The Diagnostic and Prognostic Value of Transient Elastography in Primary Biliary Cholangitis[J].Theory and Practice of Science and Technology,2025,06(12):72-74.
DOI：

Zhang Rui,Cui Lina,Ding Dawei,et al.The Diagnostic and Prognostic Value of Transient Elastography in Primary Biliary Cholangitis[J].Theory and Practice of Science and Technology,2025,06(12):72-74. DOI： 10.47297/taposatWSP2633-456915.20250612.

摘要

Abstract

Transient elastography (TE) has emerged as a pivotal noninvasive tool for assessing the liver stiffness measurement (LSM) in patients with primary biliary cholangitis (PBC). This review provides a comprehensive analysis of its diagnostic performance and its role in prognostic stratification. In terms of diagnosis

TE has demonstrated superior accuracy for staging liver fibrosis across multiple validation studies

achieving area under the receiver operating characteristic curve (AUROC) values as high as 0.99 for the detection of cirrhosis

consistently outperforming standard serological indices such as the AST-to-platelet ratio index (APRI) and the fibrosis-4 index (FIB-4). The prognostic significance of TE is profound and multifaceted. The LSM is strongly and independently correlated with the development and severity of portal hypertension and is a major driver of clinical outcomes in patients with PBC. LSM values ≥15 kPa indicate a significantly increased risk of hepatic decompensation

which is consistent with the Baveno VII consensus. In addition

the combination of TE and platelet counts can also effectively reduce unnecessary endoscopic screenings for varices.

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references

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