A Study on the Mechanism of Scutellaria Baicalensis for Eczema Based on Network Pharmacology

Yumeng Wang; Jia Li; Yu Liu; Xiaofei Zhang

doi:10.47297/taposatWSP2633-456916.20210206

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A Study on the Mechanism of Scutellaria Baicalensis for Eczema Based on Network Pharmacology

Volume 2, Issue 6

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A Study on the Mechanism of Scutellaria Baicalensis for Eczema Based on Network Pharmacology
A Study on the Mechanism of Scutellaria Baicalensis for Eczema Based on Network Pharmacology
School of Pharmacy, Shaanxi University of Chinese Medicine, Shaanxi Province, China Key Laboratory of Basic and New Drug Research in Chinese Medicine
Vol. 2, Issue 6, Pages: 101-108(2021)
Published： 2021 ，
DOI：10.47297/taposatWSP2633-456916.20210206
Accepted：

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YUMENG WANG, JIA LI, YU LIU & XIAOFEI ZHANG. (2021). A Study on the Mechanism of Scutellaria Baicalensis for Eczema Based on Network Pharmacology. Theory and Practice of Science and Technology, 2(6), 101-108..
DOI：

YUMENG WANG, JIA LI, YU LIU & XIAOFEI ZHANG. (2021). A Study on the Mechanism of Scutellaria Baicalensis for Eczema Based on Network Pharmacology. Theory and Practice of Science and Technology, 2(6), 101-108.. DOI： 10.47297/taposatWSP2633-456916.20210206.

摘要

Abstract

Objective: The active ingredients of scutellaria baicalensis are mainly flavonoids

which have good effect in the treatment of eczema

but its mechanism of action is not clear. This study explored the mechanism of action of scutellaria baicalensis in the treatment of eczema through a network pharmacological approach. Methods: The active ingredients of scutellaria baicalensis were screened and their corresponding targets were identified using a network pharmacology method. Eczema-related targets were collected

and the eczema-related microarray dataset (GSE6281) was downloaded from the GEO database and screened for differential genes by R language

and GO and KEGG enrichment analyses were performed for the core targets and their biological activities. Results: Thirty-six active components of scutellaria baicalensis were obtained

and KEGG enrichment showed that the pathways associated with scutellaria baicalensis for the treatment of eczema mainly involve chemokines

JAK-STAT

etc. Conclusion: The mechanism of action of scutellaria baicalensis in the treatment of eczema may be related to the regulation of chemokines

JAK-STAT and other signaling pathways and the expression of STAT1

JAK3

CXCR3

CXCR4

PIK3CA and EGFR targets by active ingredients such as squalene.

关键词

Keywords

Scutellaria BaicalensisEczemaNetwork PharmacologyMechanism of Action

references

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