Research Progress on the Ingredients, Pharmacological Effects, and Clinical Applications of Tongmai Jiangtang Capsule

Shuang Xu; Yu He

doi:10.47297/wspbdsWSP2752-630503.20250502

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Research Progress on the Ingredients, Pharmacological Effects, and Clinical Applications of Tongmai Jiangtang Capsule

Volume 5, Issue 2

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Research Progress on the Ingredients, Pharmacological Effects, and Clinical Applications of Tongmai Jiangtang Capsule
Research Progress on the Ingredients, Pharmacological Effects, and Clinical Applications of Tongmai Jiangtang Capsule
College of Pharmacy, Zhejiang Chinese Medical University
Vol. 5, Issue 2, Pages: 15-23(2025)
Published：18 June 2025
DOI：10.47297/wspbdsWSP2752-630503.20250502
Accepted：

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Shuang Xu,Yu He.Research Progress on the Ingredients, Pharmacological Effects, and Clinical Applications of Tongmai Jiangtang Capsule[J].Biomedical Data Science,2025,05(02):15-23.
DOI：

Shuang Xu,Yu He.Research Progress on the Ingredients, Pharmacological Effects, and Clinical Applications of Tongmai Jiangtang Capsule[J].Biomedical Data Science,2025,05(02):15-23. DOI： 10.47297/wspbdsWSP2752-630503.20250502.

摘要

Abstract

Tongmai Jiangtang Capsule (TJC) is a compound preparation that consists of 11 traditional Chinese herbs

which have the effects of clearing heat

promoting blood circulation

nourishing Yin

and alleviating heat-related conditions. Pharmacological studies have demonstrated that these herbs can enhance immune function and improve neurological function. They are often used alone or in conjunction with other pharmacological agents to manage diabetes mellitus (DM) and its coronary heart disease (CHD)

cerebral infarction (CI)

diabetic nephropathy (DN)

diabetic peripheral neuropathy (DPN)

and arteriosclerosis obliterans (ASO). This paper systematically summarizes the composition

pharmacological effects

and clinical applications of TJC in recent years. The aim is to provide support and assistance for the further research and development of this compound.

关键词

Keywords

references

Yilmire Nurmemet , Zhao HM , Reyhannisah Yakya . Clinical study on Tongmai Jiangtang Capsules combined with metformin in treatment of type 2 diabetes mellitus . Drugs & Clinic . 2019 ; 34 : 2416 - 2419 .

Harreiter J , Roden M . Diabetes mellitus: Definition, classification, diagnosis, screening and prevention (update 2023) . Wien Klin Wochenschr . 2023 ; 135 : 7 - 17 .

Dong L , Cong SQ , Cheng ML , Wang D , Shi JW . Pharmacological analysis and clinical application effects of traditional Chinese medicine Huangqi . China Hlth Stand Manag . 2024 ; 15 : 126 - 130 .

Wu J , Tong FC . Chemical composition, pharmacological action and therapeutic application of Astragalus . J Binzhou Med Univ. 2024 ; 47 : 68 - 75 .

He JJ , Qin C , He LQ , et al . Research on flavonoids of Huangqi(Astragali radix)and their pharmacological action . J Liaoning Univ Tradit Chin Med . 2024 ; 26 : 112 - 119 .

Chen LX , Liang W . Research progress on chemical constituents and pharmacological effects of Radix scrophulariae . Spec Wild Econ Anim & Plant Res . 2023 ; 45 : 147 - 151 .

Xie XX , Meng PY , Zhu LZ , et al . Study progression on pharmacology activities, chemical component and reproduction and cultivation of Pseudostellaria heterophylla . South China For Sci . 2023 ; 51 : 60 - 64,78 .

Wang YF , Lu HY , Feng XY , et al . Research progress on chemical constituents and biological activities of Pseudostellaria heterophylla . J Food Saf Qual . 2024 ; 15 : 122 - 132 .

Cheng H , Chen C , Huang J , et al . Pharmacological effects, microbial transformation and application of fermented food of Pueraria . Mod Food . 2022 ; 28 : 63 - 68 .

Ye LL , Jin H , He YH , Si ML , Hou TT , Ye LP . Research progress of berberine in the treatment of cardiovascular diseases . Clin J Tradit Chin Med . 2023 ; 35 : 174 - 178 .

Wu XH , Xun SJ , Wu WX , et al . Research progress on chemical constituents and pharmacological effects of Coptidis rhizoma . Acta Chin Med Pharmacol . 2024 ; 52 : 110 - 116 .

Wu MM , Zhou DY . Application of Huanglian (Coptidis rhizoma) and its compatibility in Xiaoke . Chin Arch Tradit Chin Med . 2024 ; 42 : 163 - 166 .

Wang Q . Research progress on pharmacological action of chemical components of Atractylodes lancea . Biol Chem Eng . 2023 ; 9 : 158 - 162 .

Jia HJ , Xu H , Huang Y , Yang MH , Yang XJ , Zhao SM . Research progress on the chemical composition and medicinal use of leeches . Chin Feed . 2024 ;( 9 ): 162 - 166 .

Wang ZX , Yang JM , Zhang ZB , et al . Chemical constituents and biological activity of Gynostemma pentaphyllum: A review . J South Agric . 2023 ; 54 : 1741 - 1752 .

Pan JZ , Meng QL , Cui WY , Zhu SJ . Advances in studies on functional components and pharmacological effects of Dioscorea opposita Thunb . Sci Technol Food Ind . 2023 ; 44 : 420 - 428 .

Qu Y , Wang T , Fu HJ , Li XL , Lei GP . Research progress on the active ingredients and pharmacological effects of Danshen (Salviae miltiorrhizae) . Chin Arch Tradit Chin Med . 2024 ; 26 : 172 - 176 .

Mao ML , Xie LY , Luo WK , et al . Research progress on pharmacological mechanisms of Danshen(Salviae miltiorrhizae radix et rhizoma) and its active ingredients on cardiovascular system . Chin Arch Tradit Chin Med . 2024 ; 42 : 120 - 124 .

Menghebilige , Wu XJ . Research progress of Mongolian medicinal material Fructus malvae . J Med & Pharm Chinese Minor . 2012 ; 18 : 37 - 40 .

Shen XX , Yang L , Li YJ . Study on mechanism of Tongmai Jiangtang Capsules in treating diabetes based on network pharmacology and molecular docking . Strait Pharm J . 2024 ; 36 : 25 - 31 .

Yang B , Wang HL . Simultaneous determination of seven components in Tongmai Jiangtang Capsules by HPLC gradient elution method . Mod Chin Med . 2020 ; 22 : 927 - 933 .

Wu YJ , Wan HF , Li C , Wan HT , Yang JH . Composition analysis and fingerprint establishment of Tongmai Jiangtang Capsule based on HPLC-Q-Exactive-MS and HPLC . Chin Tradit Herb Drugs . 2022 ; 53 : 6686 - 6697 .

Zhang B , Zhang L , Yu YB , et al . Effect of Tongmai Jiangtang Capsule on advanced glycation end products - induced apoptosis and its mechanism in Schwann cells . Chin J Neuromed . 2015 ; 14 : 1089 - 1094 .

Yang WQ , Yu YB , Xu XL , Ren HX , Zhang L . Effect of Tongmai Jiangtang Capsule on experimental diabetic peripheral neuropathy rats . Chin J Integr Tradit West Med (Chin Ed) . 2016 ; 36 : 831 - 834 .

Wang J , Liu T , Zhang JM , Tian GZ . Efficacy observation of Tongmai Jiangtang Capsules in the treatment of 75 patients with diabetes mellitus . Chin J Coal Ind Med . 2005 ; 8 : 996 - 997 .

Li JM , Xu LR , Jiang SQ . Effect of Tongmai Jiangtang Capsules on glucagon levels in type 2 diabetes mellitus . Guangming J Chin Med . 2003 ; 18 : 27 - 27 .

Tian P . Effect of adjuvant treatment with Tongmai Jiangtang Capsules on HOMA-IS and HOMA-IR levels in patients with type 2 diabetes mellitus . Pract Clin J Integr Tradit Chin & West Med . 2021 ; 21 : 129 - 130 .

Yahagi K , Kolodgie FD , Lutter C , et al . Pathology of human coronary and carotid artery atherosclerosis and vascular calcification in diabetes mellitus . Arterioscler Thromb Vasc Biol . 2017 ; 37 : 191 - 204 .

Wang Y , Guo Y , Lei Y , et al . Design and methodology of a multicenter randomized clinical trial to evaluate the efficacy of Tongmai Jiangtang Capsules in type 2 diabetic coronary heart disease patients . Front Pharmacol . 2021 ; 12 : 625785 .

Zhou YL , Han ZN , Jin DQ . Effect of thrombolytic injection on serum interleukin 6 and soluble intercellular adhesion molecule-1 levels in patients with diabetic cerebral infarction . Anhui Med Pharm J . 2016 ; 20 : 1206 - 1207 .

An XY , Xiao BC . Effect of Tongmai Jiangtang Capsule on prognosis of convalescent patients with cerebral infarction complicated with type 2 diabetes mellitus . Med & Pharm J Chin PLA . 2018 ; 30 : 83 - 87 .

Liu Y , Cui X , Zhang X , et al . Exploring the potential mechanisms of Tongmai Jiangtang Capsules in treating diabetic nephropathy through multi-dimensional data . Front Endocrinol (Laus) . 2023 ; 14 : 1172226 .

Dong Y . Efficacy observation of Tongmai Jiangtang Capsules in the treatment of 43 patients with diabetic nephropathy . Hebei J TCM . 2014 ;( 6 ): 888 - 889 .

Kong DM . Efficacy and safety evaluation of Tongmai Jiangtang Capsules in the treatment of diabetic nephropathy . Diab New World . 2015 ;( 11 ): 25 - 26 .

Wang DX , Chen C , Zhang J . Research progress on the treatment of diabetic peripheral neuropathy by traditional Chinese medicine . Diab New World . 2024 ; 27 : 196 - 198 .

Sun LX , Li YY , Xie YM . Efficacy and safety of Tongmai Jiangtang Capsule combined with conventional therapy in the treatment of diabetic peripheral neuropathy: a systematic review and meta-analysis . Front Neurol . 2023 ; 14 : 1100327 .

Chen YY , Chen Y , Zhao ZW , et al . Effect observation of Tongmai Jiangtang Capsules in treating diabetic peripheral neuropathy . Chin Mod Med . 2015 ; 22 : 148 - 150 .

Zhang AQ , Wang HF , Li ZR . Clinical observation of Tongmai Jiangtang Capsules in the treatment of diabetic peripheral neuropathy . Mod J Integr Tradit Chin West Med . 2012 ; 21 : 1068 - 1069 .

Yu JN , Lin HY , Sun AQ , Liu WM . Treatment of 40 cases of limb arteriosclerotic obliterans with Huangqi Tongmai decoction . Liaoning J Tradit Chin Med . 2006 ; 3 : 695 - 695 .

Ye XJ , Li ZH , Deng BY . Research progress on the treatment of arteriosclerosis obliterans of limbs with traditional Chinese medicine . China Med Her . 2020 ; 17 : 44 - 47 .

Zhou XD , Wang SB , Yu JW , Chen ZM , Luo LL . Efficacy observation of Tongmai Jiangtang Capsules in the treatment of 139 cases of diabetes complicated with arteriosclerosis obliterans of the limbs . Health Vocational Education . 2004 ; 22 : 106 - 107 .

Shen XJ , Li F , Hua H , Shi XT , Lv ZM . The effect of metformin combined with sitagliptin in treatment of type 2 diabetes patients and its effect on islet function . Med J West China . 2024 ; 36 : 1475 - 1479 .

Zeng WX . Study on the application effect of metformin combined with semeglutide in diabetic patients . Diab New World . 2024 ; 27 : 105 - 108 .

Bai HC . Clinical observation of Tongmai Jiangtang Capsule combined with metformin tablets in the treatment of type 2 diabetes mellitus . Chin J Mod Drug Appl . 2023 ; 17 : 49 - 52 .

Li JL , Xu LJ , Zhang YQ . Clinical study on Tongmai Jiangtang Capsules combined with metformin for diabetic nephropathy . New J Tradit Chin Med . 2019 ; 51 : 163 - 165 .

Miao KX . Study on the efficacy of α-lipoic acid combined with mecobalamin in the treatment of diabetic peripheral neuropathy . Shanxi Med J . 2021 ; 50 : 393 - 395 .

Mo GG . Efficacy observation of Tongmai Jiangtang Capsules, α-lipoic acid and mecobalamin in the combined treatment of diabetic peripheral neuropathy . Liaoning J Tradit Chin Med . 2012 ; 39 : 2227 - 2228 .

Zhang YX , Lü HH , Zhou JH , Fu XY , Wang EX . Clinical efficacy observation of modified Liuwei Dihuang pill combined with acupoint injection of vitamin B1 and B12 in the treatment of diabetic peripheral neuropathy . Chin J Integr Med Cardio-Cerebrovasc Dis . 2021 ; 19 : 2070 - 2073 .

Hao GM . Clinical efficacy observation of Tongmai Jiangtang soft capsules combined with western medicine in the treatment of 30 cases of diabetic peripheral neuropathy . Diab New World . 2015 ; 35 : 1 - 1 .

Cheng J , Du SZ , Xi WF . Study on the Effectiveness of Dulatoseptide in the Treatment of Obese Diabetes Mellitus . Diab New World . 2023 ; 26 : 77 - 80 .

Liu Y . Clinical observation of Tongmai Jiangtang capsule combined with Dulotide in treating obese type 2 diabetes mellitus . Sichuan J Physiol Sci . 2024 ; 46 : 1764 - 1766,1786 .

Xu SL , Xu QM , Li X . Clinical Effect Analysis of Sitagliptin Metformin Compound Preparation Combined with Dapagliflozin in the Treatment of Type 2 Diabetes Mellitus . Diab New World . 2024 ; 27 : 71 - 74 .

Yan XD . Observation on the Efficacy of Tongmai Jiangtang Capsules Combined with Sitagliptin in the Treatment of Type 2 Diabetes Mellitus . Phar Wkly . 2021 ; 30 ( 31 ): 48 .

Shi HT , Liang RX , Wang XN . Clinical Efficacy of Dapagliflozin in the Treatment of Type 2 Diabetic Nephropathy in the Elderly and the Effect on Renal Function . Diab New World . 2024 ; 27 : 179 - 182 .

Xie LF , Ouyang SD , Dai XX . Efficacy of Tongmai Jiangtang capsules combined with dagliflozin tablets in the treatment of type 2 diabetes mellitus and its effect on patients′ islet function . Chin J of Clinical Rational Drug Use . 2024 ; 17 : 16 - 19 .

Zhu B . Effect of Liraglutide on Adipocytokines, Blood Glucose and Renal Function Indexes in Diabetic Nephropathy Patients . Diab New World . 2024 ; 27 : 5 - 8 .

Zhang YL , Wang P , Pang S , Wang WY , He XY , Lü SL . Clinical observation of Jiangtang Tongmai Capsules combined with lilalutide in treatment of type 2 diabetes . Drugs & Clinic . 2024 ; 39 : 1824 - 1828 .

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