Anti-inflammatory effects of natural volatile organic com⁃
pounds from Pinus koraiensis and Larix kaempferi in
mouse model

doi:10.47297/wspbdsWSP2752-630504.20210101

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Anti-inflammatory effects of natural volatile organic com⁃
pounds from Pinus koraiensis and Larix kaempferi in
mouse model

Volume 1, Issue 1

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Anti-inflammatory effects of natural volatile organic com⁃ pounds from Pinus koraiensis and Larix kaempferi in mouse model
Anti-inflammatory effects of natural volatile organic com⁃ pounds from Pinus koraiensis and Larix kaempferi in mouse model
Vol. 1, Issue 1, Pages: 39-54(2021)
Published： 2021 ，
DOI：10.47297/wspbdsWSP2752-630504.20210101
Accepted：

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(2021). Anti-inflammatory effects of natural volatile organic com⁃ pounds from Pinus koraiensis and Larix kaempferi in mouse model. Biomedical Data Science, 1(1), 39-54..
DOI：

(2021). Anti-inflammatory effects of natural volatile organic com⁃ pounds from Pinus koraiensis and Larix kaempferi in mouse model. Biomedical Data Science, 1(1), 39-54.. DOI： 10.47297/wspbdsWSP2752-630504.20210101.

摘要

Abstract

Natural volatile organic compounds (VOCs) extracted from conifers such as P. koraiensis and L. kaempferi have long been studied for their anti-oxi⁃ dant

anti-proliferative

and anti-inflammatory effects. To evaluate the an⁃ ti-inflammatory effects of VOCs from P. koraiensis and L. kaempferi

lipo⁃ polysaccharide (LPS) was administered to generate a mouse model for in⁃ flammation by the nasal route to the lungs and intraperitoneally to the whole body. VOCs of P. koraiensis and L. kaempferi were exposed to the mice by standardized wood panels with closed system. Increased levels of serum IgE and PGE2 were observed after exposure to dexamethasone and VOCs. We further determined the expression levels of inflammatory cyto⁃ kine mRNA in the LPS-induced inflammation model by the reverse tran⁃ scription quantitative polymerase chain reaction. Furthermore

the levels of cyclooxygenase-2

tumor necrosis factor-α

interleukin-1β

and inter⁃ leukin-13 were determined in peripheral blood mononuclear cells. Those inflammatory cytokines and the key enzyme for inflammation cyclooxygen⁃ase-2 expression in PBMCswere strongly reversed by dexamethasone and VOCs.Lung tissuesafter nasal LPS exposure showed increased cytokine mRNA expressions which were suppressed by treat⁃ ment with dexamethasone and VOCs. Furthermore

the damage induced by LPS was attenuated by dexamethasone and VOCs. In conclusion

the results from the present study indicate that VOCs of P.koraiensisandL.kaempferihaveatherapeuticpotentialinthetreatmentorpreventionoflocaland systemicinflammationduetotheirimmunosuppressiveeffects.

关键词

Keywords

PinuskoraiensisLarixkaempferiinflammationcytokinelungs

references

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