Volume 4, Issue 3
1.The First Affiliated Hospital of Hunan Normal University (Hunan Provincial People's Hospital
2.Clinical Research Center of Sports Medicine in Hunan Province
Published： 15 October 2024 ，
Scan QR Code
LIU Di,HUANG Junjie,WU Jialong,et al.Advantages of magnesium-based alloys in orthopedics and research progress in clinical applications[J].Biomedical Data Science,2024,04(03):24-31.
LIU Di,HUANG Junjie,WU Jialong,et al.Advantages of magnesium-based alloys in orthopedics and research progress in clinical applications[J].Biomedical Data Science,2024,04(03):24-31. DOI： 10.47297/wspbdsWSP2752-630504.20240403.
In recent years
research on resorbable metal implants has gained a great deal of attention. Magnesium-based alloys have advantages in mechanical properties
biocompatibility
bioactivity
and antimicrobial potentials
but the excessive degradation rate limits their clinical applications. In order to tackle this problem
researchers have carried out various studies on surface modification techniques
and the magnesium-based screws have been certified by many countries and are now moving towards the field of clinical use. However
its clinical transformation into other orthopaedic materials still needs to solve the problem of mechanical strength as well as optimal matching of degradation behavior
where alloying and surface treatment are feasible solutions
and larger scale clinical testing and development of new types of magnesium-based implants with other functions are the directions for future research.
Magnesium-based alloysBiological activitySurface modification technologyClinical application
He X, Li Y, Zou D, Zu H, Li W, Zheng Y. An overview of magnesium-based implants in orthopaedics and a prospect of its application in spine fusion. Bioact Mater. 2024 May 30;39:456-478.
Rho JY, Kuhn-Spearing L, Zioupos P. Mechanical properties and the hierarchical structure of bone. Med Eng Phys. 1998 Mar;20(2):92-102.
Zhang Y, Xu J, Ruan YC, Yu MK, O'Laughlin M, Wise H, Chen D, Tian L, Shi D, Wang J, Chen S, Feng JQ, Chow DH, Xie X, Zheng L, Huang L, Huang S, Leung K, Lu N, Zhao L, Li H, Zhao D, Guo X, Chan K, Witte F, Chan HC, Zheng Y, Qin L. Implant-derived magnesium induces local neuronal production of CGRP to improve bone-fracture healing in rats. Nat Med. 2016 Oct;22(10):1160-1169.
Nianye Zheng, Jiankun Xu, Ye Chun Ruan, Liang Chang, Xinluan Wang, Hao Yao, Jiali Wang, Ri Zhang, Qingyun Xue, Ning Tang, Tim-yun Ong, Jörg Schilcher, Regis J. O'Keefe, Ling Qin,Magnesium facilitates the healing of atypical femoral fractures: A single-cell transcriptomic study,Materials Today,Volume 52,2022,Pages 43-62,
Li J, Ke H, Lei X, Zhang J, Wen Z, Xiao Z, Chen H, Yao J, Wang X, Wei Z, Zhang H, Pan W, Shao Y, Zhao Y, Xie D, Zeng C. Controlled-release hydrogel loaded with magnesium-based nanoflowers synergize immunomodulation and cartilage regeneration in tendon-bone healing. Bioact Mater. 2024 Feb 28;36:62-82.
Wang J, Xu J, Wang X, Sheng L, Zheng L, Song B, Wu G, Zhang R, Yao H, Zheng N, Yun Ong MT, Yung PS, Qin L. Magnesium-pretreated periosteum for promoting bone-tendon healing after anterior cruciate ligament reconstruction. Biomaterials. 2021 Jan;268:120576.
Yoshizawa S, Brown A, Barchowsky A, Sfeir C. Magnesium ion stimulation of bone marrow stromal cells enhances osteogenic activity, simulating the effect of magnesium alloy degradation. Acta Biomater. 2014 Jun;10(6):2834-42.
Han HS, Jun I, Seok HK, Lee KS, Lee K, Witte F, Mantovani D, Kim YC, Glyn-Jones S, Edwards JR. Biodegradable Magnesium Alloys Promote Angio-Osteogenesis to Enhance Bone Repair. Adv Sci (Weinh). 2020 Jun 23;7(15):2000800.
Liu W, Guo S, Tang Z, Wei X, Gao P, Wang N, Li X, Guo Z. Magnesium promotes bone formation and angiogenesis by enhancing MC3T3-E1 secretion of PDGF-BB. Biochem Biophys Res Commun. 2020 Aug 6;528(4):664-670.
Díez-Tercero L, Delgado LM, Bosch-Rué E, Perez RA. Evaluation of the immunomodulatory effects of cobalt, copper and magnesium ions in a pro inflammatory environment. Sci Rep. 2021 Jun 3;11(1):11707.
Jesú. Rodríguez-Sánchez, M.Á. Pacha-Olivenza, M.L. González-Martín, Bactericidal effect of magnesium ions over planktonic and sessile Staphylococcus epidermidis and Escherichia coli, Materials Chemistry and Physics (2018)
Li Z.; Shang Z.; Wei X.; Zhao Q. Corrosion resistance and cytotoxicity of AZ31 magnesium alloy with N+ ion implantation.Mater. Technol. 2019, 34, 730–736.
WAN G J, MAITZ M F, SUN H, et al. Corrosion properties of oxygen plasma immersion ion implantation treated magnesium [J]. Surf Coat Technol, 2007, 201(19/20): 8267–8272.
XU R, YANG X, LI P, et al. Eelectrochemical properties and corrosion resistance of carbon-ion-implanted magnesium [J]. Corros Sci, 2014, 82: 173–179.
Liu J.; Zheng Y.; Bi Y.; Li Y.; Zheng Y. Improved cytocompatibility of Mg-1Ca alloy modified by Zn ion implantation and deposition. Mater. Lett. 2017, 205, 87–89.
Lin Z, Zhao Y, Chu PK, Wang L, Pan H, Zheng Y, Wu S, Liu X, Cheung KMC, Wong T, Yeung KWK. A functionalized TiO2/Mg2TiO4 nano-layer on biodegradable magnesium implant enables superior bone-implant integration and bacterial disinfection. Biomaterials. 2019 Oct;219:119372
Liang T, Zeng L, Shi Y, Pan H, Chu PK, Yeung KWK, Zhao Y. In vitro and in vivo antibacterial performance of Zr & O PIII magnesium alloys with high concentration of oxygen vacancies. Bioact Mater. 2021 Mar 9;6(10):3049-3061.
ZHU Y, WU G, ZHANG Y H, et al. Growth and characterization of Mg(OH)2 film on magnesium alloy AZ31 [J]. Appl Surf Sci, 2011, 257(14): 6129–6137.
PENG F, LI H, WANG D H, et al. Enhanced Corrosion Resistance and Biocompatibility of Magnesium Alloy by Mg-Al-Layered Double Hydroxide[J]. ACS Applied Materials & Interfaces, 2016, 8(51): 35033-35044.
MA Fei, LI Xiang, XIE Rui-min, et al. Effect of Calcium Phosphate Coatings on Corrosion Resistance and Biocompatibility of Magnesium Alloy Scaffolds[J]. Chinese Journal of Tissue Engineering Research, 2018, 22(26): 4184-4190.
WANG Qing, WANG Wei, JIANG Da-jun, et al. Evaluation of JDBM Porous Scaffold Coated with DCPD in Promoting Angiogenesis and Repairing Bone Defects[J]. Journal of Shanghai Jiaotong University (Medical Science Edition), 2021, 41(6): 732-740.
Li Z, Sun S, Chen M, et al. In vitro and in vivo corrosion, mechanical properties and biocompatibility evaluation of MgF2-coated Mg-Zn-Zr alloy as cancellous screws[J].Materials Science and Engineering C, 2017, 75: 1268-1280.
Riaz U, Rahman ZU, Asgar H, et al. An insight into the effect of buffer layer on the electrochemical performance of MgF2 coated magnesium alloy ZK60[J]. Surface and Coatings Technology, 2018, 344: 514-521.
KANNAN S, NALLAIYAN R. Anticancer Activity of Samarium-Coated Magnesium Implants for Immunocompromised Patients[J]. ACS Applied Bio Materials, 2021, 3(7): 4408-4016.
Yang X, Li M, Lin X, et al. Enhanced in vitro biocompatibility/bioactivity of biodegradable Mg-Zn-Zr alloy by micro-arc oxidation coating contained Mg2SiO4[J]. Surface and Coatings Technology, 2013, 233: 65-73.
Liu W, Li T, Yang C, Wang D, He G, Cheng M, Wang Q, Zhang X. Lithium-Incorporated Nanoporous Coating Formed by Micro Arc Oxidation (MAO) on Magnesium Alloy with Improved Corrosion Resistance, Angiogenesis and Osseointegration. J Biomed Nanotechnol. 2019 Jun 1;15(6):1172-1184.
Zhu B, Wang L, Wu Y, Yue W, Liang J, Cao B. Improving corrosion resistance and biocompatibility of AZ31 magnesium alloy by ultrasonic cold forging and micro-arc oxidation. J Biomater Appl. 2022 Apr;36(9):1664-1675.
Guo, Jingjing; Liu, Xianfeng; Du, Keqin; Guo, Quanzhong; Wang, Yong; Liu, Yunyan; Feng, Li (2019). An anti-stripping and self-healing micro-arc oxidation/acrylamide gel composite coating on magnesium alloy AZ31. Materials Letters.Volume 260.2020.126912.
Related Articles
Related Author
Related Institution
京公网安备11010802024621