Volume 5, Issue 2
School of Jiangnan University, Jiangsu, Wuxi 214000, China
Published：18 June 2025
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Lou Haina.Exploring the role of the core mechanism of curcumin in the regulation of fat metabolism[J].Biomedical Data Science,2025,05(02):30-34.
Lou Haina.Exploring the role of the core mechanism of curcumin in the regulation of fat metabolism[J].Biomedical Data Science,2025,05(02):30-34. DOI： 10.47297/wspbdsWSP2752-630505.20250502.
Curcumin is a bioactive polyphenol from Curcuma longa which has the potential to regulate fat metabolism. This review explored the mechanisms of curcumin in fat metabolism. Subsequently
the modulation of AMPK and mTORC1-TFEB pathways
lipid oxidation enhancement
inhibition of adipogenesis
and influence on gut microbiota composition were reviewed. However
the major limiting factor is its bioavailability; hence
nanoformulations
liposomes
and synergistic combinations of therapy must be advanced in the future. Curcumin derivatives
delivery technologies
and clinical validation to be used as functional foods or in metabolic disorder treatments should be the focus of future research. As a natural
multi-targeted intervention
curcumin holds significant potential in fat metabolism regulation. Thus it requires further examination and optimization of clinical applications.
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