Research on Mechanism of Traditional Chinese Medicine and Rehabilitation Treatment of IBS from Intestinal Flora

Juanfang Wei; Defang Yang

doi:10.47297/wspbdsWSP2752-630507.20250502

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Research on Mechanism of Traditional Chinese Medicine and Rehabilitation Treatment of IBS from Intestinal Flora

Volume 5, Issue 2

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Research on Mechanism of Traditional Chinese Medicine and Rehabilitation Treatment of IBS from Intestinal Flora
Research on Mechanism of Traditional Chinese Medicine and Rehabilitation Treatment of IBS from Intestinal Flora
1.School of Sports and Health, Geely University, Chengdu 641423, Sichuan, China
2.Yining Health School, Yining 835000, Xinjiang, China
Vol. 5, Issue 2, Pages: 41-45(2025)
Published：18 June 2025
DOI：10.47297/wspbdsWSP2752-630507.20250502
Accepted：

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Wei Juanfang,Yang Defang.Research on Mechanism of Traditional Chinese Medicine and Rehabilitation Treatment of IBS from Intestinal Flora[J].Biomedical Data Science,2025,05(02):41-45.
DOI：

Wei Juanfang,Yang Defang.Research on Mechanism of Traditional Chinese Medicine and Rehabilitation Treatment of IBS from Intestinal Flora[J].Biomedical Data Science,2025,05(02):41-45. DOI： 10.47297/wspbdsWSP2752-630507.20250502.

摘要

Abstract

Objective To Irritable bowel syndrome(IBS) is a recurrent functional gastrointestinal disease. There is no organic change in IBS

and its pathophysiology is not completely clear. At present

the pathogenesis of IBS includes genetic factors

food intolerance

abnormal intestinal motility

visceral hypersensitivity

abnormal brain gut axis regulation

intestinal flora imbalance

intestinal infection and immune factors

as well as psychological factors. Traditional Chinese medicine

as the dominant subject of gastrointestinal diseases

has good clinical effect and is not easy to relapse. It has obvious effect in the treatment of IBS and is widely used. This article will review the importance of traditional Chinese medicine in the treatment of IBS

intestinal flora in the prevention and treatment of IBS

and the research progress of IBS rehabilitation intervention.

关键词

Keywords

references

Van den Houte K , Colomier E , Schol J , et al . Recent advances in diagnosis and management of irritable bowel syndrome [J ] . Curr Opin Psychiatry , 2020 , 33 ( 5 ): 460 - 466 .

Wu H , Zhang Z Y . Consensus on the treatment of irritable bowel syndrome(2018,America) [J ] . Chin J Microecol , 2019 , 31 ( 08 ): 944 - 946 .

Zhou S Y , Gillilland M , Wu X , et al . FODMAP diet modulates visceral nociception by lipopolysaccharide-mediated intestinal inflammation and barrier dysfunction [J ] . J Clin Invest , 2018 , 128 ( 1 ): 267 - 280 .

Bharucha A E , Lacy B E . Mechanisms, Evaluation, and Management of Chronic Constipation [J ] . Gastroenterology , 2020 , 158 ( 5 ): 1232 - 1249 .

Yang F , Yan J , Liu L N , et al . New progress in etiology and pathogenesis of irritable bowel syndrome [J ] . J Hebei Med Univ , 2020 , 41 ( 08 ): 987 - 992 .

Zhang J , Song L , Wang Y , et al . Beneficial effect of butyrate-producing Lachnospiraceae on stress-induced visceral hypersensitivity in rats [J ] . J Gastroenterol Hepatol , 2019 . 34 ( 8 ): 1368 - 1376 .

Grundy L , Erickson A , Brierley S M . Visceral Pain [J ] . Annu Rev Physiol , 2019 , 81 : 261 - 284 .

Burns G , Carroll G , Mathe A , et al . Evidence for Local and Systemic Immune Activation in Functional Dyspepsia and the Irritable Bowel Syndrome: A Systematic Review [J ] . Am J Gastroenterol , 2019 , 114 ( 3 ): 429 - 436 .

Pimentel M , Lembo A . Microbiome and Its Role in Irritable Bowel Syndrome [J ] . Dig Dis Sci , 2020 , 65 ( 3 ): 829 - 839 .

Cowan C S M , Hoban A E , Ventura-Silva A P , et al . Gutsy Moves: The Amygdala as a Critical Node in Microbiota to Brain Signaling [J ] . Bioessays , 2018 , 40 ( 1 ).

Plaza-Diaz J , Ruiz-Ojeda F J , Gil-Campos M , et al . Mechanisms of Action of Probiotics [J ] . Adv Nutr , 2019 , 10 ( 1 ): 49 - 66 .

Johnsen P H , Hilpusch F , Cavanagh J P , et al . Faecal microbiota transplantation versus placebo for moderate-to-severe irritable bowel syndrome: a double-blind, randomised, placebo-controlled, parallel-group, single-centre trial [J ] . Lancet Gastroenterol Hepatol , 2018 , 3 ( 1 ): 17 - 24 .

Jr Kastl A J , Terry N A , Wu G D , et al . The Structure and Function of the Human Small Intestinal Microbiota: Current Understanding and Future Directions [J ] . Cell Mol Gastroenterol Hepatol , 2020 , 9 ( 1 ): 33 - 45 .

Aslam H , Green J , Jacka F N , et al . Fermented foods, the gut and mental health: a mechanistic overview with implications for depression and anxiety [J ] . Nutr Neurosci , 2020 . 23 ( 9 ): 659 - 671 .

Martin C R , Osadchiy V , Kalani A , et al . The Brain-Gut-Microbiome Axis [J ] . Cell Mol Gastroenterol Hepatol , 2018 , 6 ( 2 ): 133 - 148 .

Zhang S S , Wei W , Yang J Q . Expert consensus on TCM diagnosis and treatment of irritable bowel syndrome [J ] . J Tradit Chin Med , 2017 , 58 ( 18 ): 1614 - 1620 .

Song J , Yang L , Su S , et al . The Diagnosis Performance of the TCM Syndromes of Irritable Bowel Syndrome by Gastroenterologists Based on Modified Simple Criteria Compared to TCM Practitioners: A Prospective, Multicenter Preliminary Study [J ] . Evid Based Complement Alternat Med , 2020 , 2020 : 9507674 .

Zhao J , Yan J L , Li L J . Analysis of the rule of traditional Chinese medicine in the treatment of irritable bowel syndrome [J ] . Acta Chin Med , 2015 , 30 ( 04 ): 586 - 589 .

Cui L N , Liu L L , Wang S , et al . Research progress of TCM treatment of irritable bowel syndrome [J ] . J Int TCM , 2018 , 40 ( 7 ): 673 - 676 .

Li J X , Chen J , Tang X D , et al . Consensus on the diagnosis and treatment of irritable bowel syndrome by integrated traditional Chinese and western medicine [J ] . Chin J Intege Tradit West Med Digestion , 2018 , 26 ( 03 ): 227 - 232 .

Bian L Q , Chen T , Tang X D , et al . Analysis of TCM treatment mode of irritable bowel syndrome [J ] . Global Chinese Medicine , 2015 ( 1 ): 119 - 123 .

Qian Y D , Huang X , Zhen H B . Acta Chin Med Pharm , 2018 , 46 ( 06 ): 102 - 105 .

Jin Y Q , Zhan D W , Luo K T , et al . Shanghai Journal of Acupuncture and Moxibustion , 2017 , 36 ( 6 ): 684 - 687 .

Li Q . Clinical study on the treatment of diarrhea-type irritable bowel syndrome by Sanfu acupoint application combined with acupuncture and moxibustion [D ] , 2014 , Chengdu University of TCM.

Xiong R , Li W , Li Y , et al . Er Shen Wan extract reduces diarrhea and regulates AQP 4 and NHE 3 in a rat model of spleen-kidney Yang deficiency-induced diarrhea [J ] . Biomed Pharmacother , 2018 , 98 : 834 - 846 .

Yang S , Zhang J , Yan Y , et al . Network Pharmacology-Based Strategy to Investigate the Pharmacologic Mechanisms of Atractylodes macrocephala Koidz. for the Treatment of Chronic Gastritis [J ] . Front Pharmacol , 2019 , 10 : 1629 .

Zhao X Y , Wang J W , Yin Y , et al . Effect of Tong Xie Yao Fang on endogenous metabolites in urine of irritable bowel syndrome model rats [J ] . World J Gastroenterol , 2019 , 25 ( 34 ): 5134 - 5151 .

Chao G , Zhang S . The characteristics of intestinal flora of IBS-D with different syndromes [J ] . Immun Inflamm Dis , 2020 , 8 ( 4 ): 615 - 628 .

Peng S Y , Liu X , Qin K M , et al . J Nangjing Univ Tradit Chion Med , 2020 , 36 ( 05 ): 641 - 646 .

Ma Q , Ouyang Y , Meng F , et al . A review of pharmacological and clinical studies on the application of Shenling Baizhu San in treatment of Ulcerative colitis [J ] . J Ethnopharmacol , 2019 , 244 : 112105 .

Shi K , Qu L , Lin X , et al . Deep-Fried Atractylodis Rhizoma Protects against Spleen Deficiency-Induced Diarrhea through Regulating Intestinal Inflammatory Response and Gut Microbiota [J ] . Int J Mol Sci , 2019 , 21 ( 1 ).

Liu J H , Wang L D , Wang M L , et al . Research progress of intestinal flora associated with irritable bowel syndrome and its treatment [J ] . study of TCM , 2020 . 33 ( 06 ): 71 - 75 .

Lian Q , Ding H , Zhu H , et al . Study of Jianpi Mixture on Intestinal Microbiota of Diarrhea Irritable Bowel Syndrome Mice [J ] . Evid Based Complement Alternat Med , 2020 , 2020 : 5241308 .

Liu S , Shi Q , Zhu Q , et al . P2X₇ receptor of rat dorsal root ganglia is involved in the effect of moxibustion on visceral hyperalgesia [J ] . Purinergic Signal , 2015 . 11 ( 2 ): 161 - 9 .

Zhou Y Y , Wanner N J , Xiao Y , et al . Electroacupuncture alleviates stress-induced visceral hypersensitivity through an opioid system in rats [J ] . World J Gastroenterol , 2012 , 18 ( 48 ): 7201 - 11 .

Guo X , Chen J , Lu y , et al . Electroacupuncture at He-Mu points reduces P2X4 receptor expression in visceral hypersensitivity [J ] . Neural Regen Res , 2013 , 8 ( 22 ): 2069 - 77 .

Chen Y , Zhao Y , Luo D N , et al . Electroacupuncture Regulates Disorders of Gut-Brain Interaction by Decreasing Corticotropin-Releasing Factor in a Rat Model of IBS [J ] . Gastroenterol Res Pract , 2019 , 2019 : 1759842 .

Bao C H , Wang C Y , Li G N , et al . Effect of mild moxibustion on intestinal microbiota and NLRP6 inflammasome signaling in rats with post-inflammatory irritable bowel syndrome [J ] . World J Gastroenterol , 2019 , 25 ( 32 ): 4696 - 4714 .

Bai J Q , Liu Y Y , Gao Z F . Advances in non-drug therapy of irritable bowel syndrome [J ] . J Clinical Experim Med . 2020 , 19 ( 13 ): 1455 - 1457 .

Du R H , Song G , Zhao J C . From correlation to causation: movement and the gut microbiota-gut-brain axis [J ] . China Sports Science and Technology , 2020 , 56 ( 11 ): 78 - 83 .

Song S H , Song Q S , Zhang X F , et al . Effect of ultrashort wave on immune function in patients with irritable bowel syndrome [J ] . Chin J Phys Med Rehabil , 2003 , 25 ( 10 ): 623 - 625 .

Wang M X , Song D L , Jian J . Effect of electromyography biofeedback on visceral pain sensitivity in refractory irritable bowel syndrome [J ] . Chin J Phys Med Rehabil , 2009 , 31 ( 1 ): 26 - 29 .

Mou Y Q , Liu X S , Wei Y L . Progress in clinical application of percutaneous acupoint electrical stimulation [J ] . J Changchun Univ Tradit Chin Med , 2017 , 33 ( 1 ): 169 - 171 .

Zhang Y H , Shi Z L , Han P . Psychological status of irritable bowel syndrome patients [J ] . Chin J Rehabil Theory Pract , 2007 . 13 ( 2 ): 79 - 180 .

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