Mechanisms and Targeted Research Advances of the PI3K/AKT Pathway in Drug Resistance and Immune Microenvironment Regulation of HER2-Positive Breast Cancer

Yuan Dai

doi:10.47297/wspbdsWSP2752-630513.20260601

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Mechanisms and Targeted Research Advances of the PI3K/AKT Pathway in Drug Resistance and Immune Microenvironment Regulation of HER2-Positive Breast Cancer

Volume 6, Issue 1

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Mechanisms and Targeted Research Advances of the PI3K/AKT Pathway in Drug Resistance and Immune Microenvironment Regulation of HER2-Positive Breast Cancer
Mechanisms and Targeted Research Advances of the PI3K/AKT Pathway in Drug Resistance and Immune Microenvironment Regulation of HER2-Positive Breast Cancer
Shandong Xiehe University, Jinan, Shandong, 250000, China
Vol. 6, Issue 1, Pages: 58-61(2026)
Published：30 March 2026
DOI：10.47297/wspbdsWSP2752-630513.20260601
Accepted：

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Yuan Dai.Mechanisms and Targeted Research Advances of the PI3K/AKT Pathway in Drug Resistance and Immune Microenvironment Regulation of HER2-Positive Breast Cancer[J].Biomedical Data Science,2026,06(01):58-61.
DOI：

Yuan Dai.Mechanisms and Targeted Research Advances of the PI3K/AKT Pathway in Drug Resistance and Immune Microenvironment Regulation of HER2-Positive Breast Cancer[J].Biomedical Data Science,2026,06(01):58-61. DOI： 10.47297/wspbdsWSP2752-630513.20260601.

摘要

Abstract

HER2-positive breast cancer accounts for 20–30% of all breast cancer cases

exhibiting high invasiveness and poor prognosis. Anti-HER2 targeted therapy remains the core clinical treatment strategy; however

30–50% of patients develop primary or acquired resistance

presenting a significant therapeutic bottleneck.Abnormal activation of the PI3K/AKT pathway is a key mechanism mediating targeted resistance in this subtype of breast cancer

exhibiting close cross-regulatory interactions with the immunosuppressive state of the tumour immune microenvironment.This paper systematically reviews the regulatory mechanisms of the PI3K/AKT pathway in HER2-positive breast cancer targeted resistance

analyses its interaction patterns with the immune microenvironment

and summarises advances in combination therapy targeting this pathway. Findings indicate that the PI3K/AKT pathway synergistically mediates targeted resistance through regulating cell proliferation and immune molecule expression

leading to immune escape. - immune escape. Concurrently

combination regimens incorporating pathway inhibitors with anti-HER2 agents and immune checkpoint inhibitors demonstrate promising therapeutic potential. This study provides theoretical foundations for elucidating the nature of resistance in HER2-positive breast cancer and offers novel insights for developing personalised combination treatment strategies in clinical practice.

关键词

Keywords

references

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