Research on the Mechanism of Action of Chlorin-based Photosensitizers in Photodynamic Therapy for Tumors

Chaoyu Feng

doi:10.47297/wspbdsWSP2752-630515.20260601

PDF
Export
Share
Collection
Album

Research on the Mechanism of Action of Chlorin-based Photosensitizers in Photodynamic Therapy for Tumors

Volume 6, Issue 1

Views: 0 Downloads: 0

Research on the Mechanism of Action of Chlorin-based Photosensitizers in Photodynamic Therapy for Tumors
Research on the Mechanism of Action of Chlorin-based Photosensitizers in Photodynamic Therapy for Tumors
Shandong Second Medical University, Jinan, Shandong, 261053, China
Vol. 6, Issue 1, Pages: 68-72(2026)
Published：30 March 2026
DOI：10.47297/wspbdsWSP2752-630515.20260601
Accepted：

Scan QR Code

Feng Chaoyu.Research on the Mechanism of Action of Chlorin-based Photosensitizers in Photodynamic Therapy for Tumors[J].Biomedical Data Science,2026,06(01):68-72.
DOI：

Feng Chaoyu.Research on the Mechanism of Action of Chlorin-based Photosensitizers in Photodynamic Therapy for Tumors[J].Biomedical Data Science,2026,06(01):68-72. DOI： 10.47297/wspbdsWSP2752-630515.20260601.

摘要

Abstract

In recent years

researchers have improved the solubility

tumor enrichment ability and photodynamic effect of cyanine-based photosensitizers by modifying their skeletons

adding hydrophilic groups

targeting ligands or constructing nano-aggregates. However

there is less research on the mechanism of action of cyanine-based photosensitizers

and the development of cyanine-based photosensitizer derivatives has broad prospects. This thesis takes the mechanism of action of cyanine-based photosensitizers as the main line

not only designs a series of new derivatives through chemical synthesis and structural analysis

but also reveals their structure-activity relationship and biological characteristics through the determination of photophysical properties and reactive oxygen species generation experiments (MTT method).This work is conducive to clarifying the molecular action pathways of cyanine-based photosensitizers in PDT

and provides a theoretical basis and technical route for the development of efficient

low-toxic and transferable third-generation photosensitizers. Through the study of photosensitivity

the cell activity of the products is analyzed by mass spectrometry

and the molecular structure is determined by mass spectrometry and other methods. This is of great significance for promoting the research of high-end anti-cancer drugs in China and the development of the precision medical industry.

关键词

Keywords

references

Wen Yanan . Research on Fluorescence Spectral Characteristics of Porphyrin and Quantum Dot Photosensitizers [D ] . Harbin Institute of Technology , 2010 .

Liu Yonglong , Zhu Luzhou , Wu Peng , Yang Shilin . Research on Yangzhou Photoporphyrin (YHPD), a Porphyrin-Based Photosensitizing Drug [J ] . Acta Pharmaceutica Sinica , 1985 , ( 08 ): 619 - 622 .

Fu Naiwu , Yan Lixue . Research on the photosensitive reaction and preventive drugs of phthalocyanine-type photosensitizers on mouse skin [J ] . Chinese Journal of Laser Medicine , 1993 , ( 01 ): 33 - 37 .

Ma Zhiqiang . Dihydropterin-type photosensitizers & amp; amp; amp; Design, Synthesis and Mechanism Study of HDACi Dual-Mode Anti-Tumor Drugs [D ] . Supervisor : Yao Jianzhong. Naval Medical University of the People's Liberation Army of China , 2020 .

Shen Yujie . Study on the Role and Mechanism of the New Photosensitizer Chlorophyll Light No . Ⅰ in Photodynamic Therapy for Pancreatic Cancer [D ] . Shanghai Jiao Tong University , 2019 .

Ye Biwei . Study on the Mechanism of PI3K 110 Inhibitor Enhancing Photodynamic Therapy of Curcumin in Multidrug-Resistant Tumors [D ] . Fujian Agriculture and Forestry University , 2023 .

Hui Tan ; Hou Dongsheng . Research Progress on the Mechanism of Photodynamic Therapy for Malignant Tumors [J ] . Lingnan Modern Clinical Surgery , 2013 ( 02 ): 88 - 91 .

Xueze Zhao , et al . An Approach to Developing Cyanines with Simultaneous Intersystem Crossing Enhancement and Excited-State Lifetime Elongation for Photodynamic Antitumor Metastasis . JACS , 2021 .

Anjos D J P R A , Pinto S D N M , Porto L D , et al . Analytical Quality by Design approach in the development of a green reversed-phase ultra-high performance liquid chromatography/high-resolution time-of-flight mass spectrometry method for the simultaneous analysis of synthetic antimicrobial and hypotensive peptides [J ] . Journal of Chromatography Open , 2026 , 9100318 - 100318 .

Wu Gixian , Zhao Haifeng , Huang Weifeng , et al .. Study on the Fine Structure of LiFexMn1-xO2 Based on X-ray Absorption Spectroscopy Using Synchrotron Radiation (English) [J ] . Journal of University of Science and Technology of China , 2017 , 47 ( 05 ): 369-376 + 391 .

Feeney J W , Choucair I . Advances in Chromatography-Free and Ambient Ionization Mass Spectrometry Techniques Toward Clinical Toxicology Testing .[J ] . Clinics in laboratory medicine , 2025 , 45 ( 2 ): 187 - 205 .

Karakuyu F N , Polat K H , Unal S , et al . Development of nimesulide-loaded pH-triggered ocular in situ gels; In vitro characterization, MTT assay and Drazie test .[J ] . Drug development and industrial pharmacy , 2026 , 1 - 12 .

Bahmani A , Ebadi A , Yeganeh P H , et al . New Coumarin Derivatives as Cytotoxic Agents: Synthesis, in silico DNA-Binding Studies and MTT Assays in the MCF-7 Cell Line [J ] . Organic Preparations and Procedures International , 2026 , 58 ( 2 ): 159 - 168 .

Alert me when the article has been cited

Submit

No data

Related Author

No data

Related Institution

No data

⁰