Research Progress on E-cadherin in Breast Cancer Metastasis

Lingfei Yue

doi:10.47297/wspbdsWSP2752-630527.20250501

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Research Progress on E-cadherin in Breast Cancer Metastasis

Volume 5, Issue 1

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Research Progress on E-cadherin in Breast Cancer Metastasis
Research Progress on E-cadherin in Breast Cancer Metastasis
Huazhong university of science and technology, Wuhan, Hubei, 430074
Vol. 5, Issue 1, Pages: 120-124(2025)
Published：19 March 2025
DOI：10.47297/wspbdsWSP2752-630527.20250501
Accepted：

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Yue Lingfei.Research Progress on E-cadherin in Breast Cancer Metastasis[J].Biomedical Data Science,2025,05(01):120-124.
DOI：

Yue Lingfei.Research Progress on E-cadherin in Breast Cancer Metastasis[J].Biomedical Data Science,2025,05(01):120-124. DOI： 10.47297/wspbdsWSP2752-630527.20250501.

摘要

Abstract

Breast cancer

a malignant tumor

poses a significant threat to women's health globally

with metastasis being the primary cause of its high mortality rate. E-cadherin

a crucial cell-cell adhesion molecule

plays a pivotal role in the metastasis of breast cancer. This article aims to examine the molecular mechanisms underlying E-cadherin's involvement in breast cancer metastasis and its potential as a therapeutic target. The inactivation mechanism of E-cadherin in breast cancer is diverse

including gene mutation and loss of heterozygosity

DNA methylation modification

transcriptional level regulation

protein glycosylation modification

and the influence of inflammation and related signaling pathways. These alterations result in the dysfunction of E-cadherin and promote cancer metastasis. The targeted therapy research for E-cadherin has made continuous progress

including strategies such as restoring its expression

stabilizing its structure

utilizing synthetic lethal effects

and intervening in related abnormal pathways.

关键词

Keywords

references

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