Roles of GNA13 in Various Types of Cancer

Xu Wang

doi:10.47297/wspbdsWSP2752-630529.20250502

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Roles of GNA13 in Various Types of Cancer

Volume 5, Issue 2

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Roles of GNA13 in Various Types of Cancer
Roles of GNA13 in Various Types of Cancer
College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi Province, 712100, China
Vol. 5, Issue 2, Pages: 157-160(2025)
Published：18 June 2025
DOI：10.47297/wspbdsWSP2752-630529.20250502
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Xu Wang.Roles of GNA13 in Various Types of Cancer[J].Biomedical Data Science,2025,05(02):157-160.
DOI：

Xu Wang.Roles of GNA13 in Various Types of Cancer[J].Biomedical Data Science,2025,05(02):157-160. DOI： 10.47297/wspbdsWSP2752-630529.20250502.

摘要

Abstract

GNA13

a component of the G protein signaling network

is involved in regulating cancer cell growth

migration

and programmed cell death. Recent evidence has shown increased levels of GNA13 across several tumor types

including breast

prostate

stomach

and liver cancers

closely linking its expression to tumor progression

spread

and patient outcomes. This article systematically reviews GNA13 expression across diverse cancers and explores its functional impact on tumor biology. Particular attention is given to the pathways through which GNA13 enhances cancer progression

specifically by stimulating AKT

ERK

and MYC signaling and suppressing FOXO1. Current research identifies GNA13 as an emerging biomarker and potential target for cancer diagnosis and therapy

paving the way for future treatment innovations.

关键词

Keywords

references

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Ayoub M. , et al . 2012 . G-protein signaling and its role in breast cancer: From mechanisms to therapeutics . Trends in Pharmacological Sciences , 33 ( 1 ), 24 – 33 .

Subramanyan L. V. , Rasheed S . A . K., Wang L. , Ghosh S., Ong M. S . N., LakshmananM., WangM., & CaseyP. J. ( 2024 ). GNA13 suppresses proliferation of ER+ breast cancer cells via ERα-dependent upregulation of the MYC oncogene. Breast Cancer Research, 26 , Article 113.

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Yan H. , et al . 2023 . An Update of G-Protein-Coupled Receptor Signaling and Its Deregulation in Gastric Carcinogenesis . Cancers , 15 , 736 .

Xu M. , et al . ( 2016 ). High expression of GNA13 is associated with poor prognosis in hepatocellular carcinoma . Scientific Reports , 6 , 35948 .

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