Studies on the Biocompatibility and Targeting Properties of Magnetic Nanomaterials

Xinyuan Xing

doi:10.47297/wspbdsWSP2752-630534.20250503

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Studies on the Biocompatibility and Targeting Properties of Magnetic Nanomaterials

Volume 5, Issue 3

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Studies on the Biocompatibility and Targeting Properties of Magnetic Nanomaterials
Studies on the Biocompatibility and Targeting Properties of Magnetic Nanomaterials
School of physics and electronics, Shandong Normal University, Jinan, Shandong, 250000, China
Vol. 5, Issue 3, Pages: 166-170(2025)
Published：30 September 2025
DOI：10.47297/wspbdsWSP2752-630534.20250503
Accepted：

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Xing Xinyuan.Studies on the Biocompatibility and Targeting Properties of Magnetic Nanomaterials[J].Biomedical Data Science,2025,05(03):166-170.
DOI：

Xing Xinyuan.Studies on the Biocompatibility and Targeting Properties of Magnetic Nanomaterials[J].Biomedical Data Science,2025,05(03):166-170. DOI： 10.47297/wspbdsWSP2752-630534.20250503.

摘要

Abstract

This study aims to explore the biocompatibility and targeting of folate modified magnetic iron oxide nanoparticles

and provide a theoretical basis for the precise diagnosis and treatment of tumors. In this experiment

nanoparticles were prepared by chemical synthesis and folic acid molecules were modified onto their surface to form FA- Fe

MNPs. Fourier transform infrared (FTIR) spectroscopy was used to verify whether folic acid was successfully coupled to the Fe

nanoparticles; and a CCK-8 assay was used to assess the effect of FA-Fe₃O₄ MNPs on the cytotoxicity of HK2 cells and HeLa cells. Meanwhile

the uptake of FITC-labelled FA-Fe₃O₄ MNPs by both cells was observed. FTIR characterisation showed that folic acid was successfully modified on the surface of Fe₃O₄ nanoparticles. In CCK-8 experiments

12.5 and 25 μg/mL of FA-Fe₃O₄ MNPs were virtually non-toxic to HK2 cells and HeLa cells

and cell viability was maintained at a high level

whereas cell viability decreased at higher concentrations. Cellular uptake assays showed that HeLa cells showed significantly higher uptake of FITC-labelled FA-Fe₃O₄ MNPs than HK2 cells. FA-Fe₃O₄ MNPs have good biocompatibility and targeting properties

and can effectively target tumour cells with high folate receptor α expression.

关键词

Keywords

references

Mukherjee S , Liang L , Veiseh O . Recent advancements of magnetic nanomaterials in cancer therapy [J ] . Pharmaceutics , 2020 , 12 ( 2 ): 147 .

Luqmani Y . Mechanisms of drug resistance in cancer chemotherapy [J ] . Medical Principles & Practice , 2005 , 14 .

Liu X , Zhang H , Zhang T , et al . Magnetic nanomaterials-mediated cancer diagnosis and therapy [J ] . Progress in Biomedical Engineering , 2021 , 4 ( 1 ): 012005 .

Nordin A H , Ahmad Z , Husna S M N , et al . The state of the art of natural polymer functionalized Fe3O4 magnetic nanoparticle composites for drug delivery applications: A review [J ] . Gels , 2023 , 9 ( 2 ): 121 .

Rukhsar M , Ahmad Z , Rauf A , et al . An overview of iron oxide (Fe3O4) nanoparticles: From synthetic strategies, characterization to antibacterial and anticancer applications [J ] . Crystals , 2022 , 12 ( 12 ): 1809 .

Arriortua O K , Insausti M , Lezama L , et al . RGD-Functionalized Fe3O4 nanoparticles for magnetic hyperthermia [J ] . Colloids and Surfaces B: Biointerfaces , 2018 , 165 : 315 - 324 .

Lamichhane N , Sharma S , Parul , et al . Iron oxide-based magneto-optical nanocomposites for in vivo biomedical applications [J ] . Biomedicines , 2021 , 9 ( 3 ): 288 .

Chen C , Ke J , Zhou X E , et al . Structural basis for molecular recognition of folic acid by folate receptors [J ] . Nature , 2013 , 500 ( 7463 ): 486 - 489 .

Hong L , Li W , Li Y , et al . Nanoparticle-based drug delivery systems targeting cancer cell surfaces [J ] . RSC advances , 2023 , 13 ( 31 ): 21365 - 21382 .

Gonzalez T , Muminovic M , Nano O , et al . Folate receptor alpha—a novel approach to cancer therapy [J ] . International Journal of Molecular Sciences , 2024 , 25 ( 2 ): 1046 .

Scaranti M , Cojocaru E , Banerjee S , et al . Exploiting the folate receptor α in oncology [J ] . Nature reviews clinical oncology , 2020 , 17 ( 6 ): 349 - 359 .

Jiang Q , Zheng S , Hong R , et al . Folic acid-conjugated Fe3O4 magnetic nanoparticles for hyperthermia and MRI in vitro and in vivo [J ] . Applied Surface Science , 2014 , 307 : 224 - 233 .

Narmani A , Rezvani M , Farhood B , et al . Folic acid functionalized nanoparticles as pharmaceutical carriers in drug delivery systems [J ] . Drug development research , 2019 , 80 ( 4 ): 404 - 424 .

Wang Q , Cheng Y , Wang W , et al . Polyetherimide‐and folic acid‐modified Fe3O4 nanospheres for enhanced magnetic hyperthermia performance [J ] . Journal of Biomedical Materials Research Part B: Applied Biomaterials , 2023 , 111 ( 4 ): 795 - 804 .

Bahmani A , Taghvaei A , Firozian F , et al . Folic Acid as an Exploiter of Natural Endocytosis Pathways in Drug Delivery [J ] . Chem Methodologies , 2024 , 8 : 96 - 122 .

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