Development and Verification of an Improved Method for Establishing a Pulmonary Fibrosis Mouse Model

Nan Mo; Shangfu Xu; Chan Liu; Zhenhai Fan

doi:10.47297/wspbtsWSP2755-952110.20250402

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Development and Verification of an Improved Method for Establishing a Pulmonary Fibrosis Mouse Model

Volume 4, Issue 2

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Development and Verification of an Improved Method for Establishing a Pulmonary Fibrosis Mouse Model
Development and Verification of an Improved Method for Establishing a Pulmonary Fibrosis Mouse Model
Key Laboratory of Cell Engineering of Guizhou Province, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, 563000 ,China
Vol. 4, Issue 2, Pages: 47-51(2025)
Published：30 June 2025
DOI：10.47297/wspbtsWSP2755-952110.20250402
Accepted：

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Mo Nan,Xu Shangfu,Liu Chan,et al.Development and Verification of an Improved Method for Establishing a Pulmonary Fibrosis Mouse Model[J].Biomedical Testing & Sensing,2025,04(02):47-51.
DOI：

Mo Nan,Xu Shangfu,Liu Chan,et al.Development and Verification of an Improved Method for Establishing a Pulmonary Fibrosis Mouse Model[J].Biomedical Testing & Sensing,2025,04(02):47-51. DOI： 10.47297/wspbtsWSP2755-952110.20250402.

摘要

Abstract

Idiopathic pulmonary fibrosis (IPF) is a severe lung disease with multiple underlying causes

and effective treatments are unavailable due to its complicated pathogenesis. Animal models are commonly used to explore the pathogenesis of IPF and to develop new drugs. However

due to the most widely used method of intratracheal administration

via tracheotomy and tracheal instillation

lead to asphyxia and high mortality of mice during the modeling process

a more appropriate IPF animal model to better understand IPF is a dire clinical need. Therefore

this study aimed to improve the endotracheal intubation procedure and validate the model. The improved tracheal intubation method proposed in this study is straightforward and easy to implement

and the animal model was accepted with the hallmark characteristics of IPF. Therefore

if adopted

this methodology can potentially better understanding of the pathogenesis of IPF and facilitates the development of pharmacological agents to overcome IPF.

关键词

Keywords

references

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