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3卷 第6期
Association between KIR Gene Polymorphism and Diabetes After Liver Transplantation
Association between KIR Gene Polymorphism and Diabetes After Liver Transplantation
- 2022年3卷第6期 页码:66-69
DOI:10.47297/taposatWSP2633-456910.20220306
Full txt
3卷 第6期
The Affiliated Calmette Hospital of Kunming Medical University
Full txt
(2022). Association between KIR Gene Polymorphism and Diabetes After Liver Transplantation. 科技理论与实践(英文版), 3(6), 66-69.
Liu Fang,Han Lei,Zhang Xibing.Association between KIR Gene Polymorphism and Diabetes After Liver Transplantation[J].Theory and Practice of Science and Technology,2022,03(06):66-69.
(2022). Association between KIR Gene Polymorphism and Diabetes After Liver Transplantation. 科技理论与实践(英文版), 3(6), 66-69. DOI: 10.47297/taposatWSP2633-456910.20220306.
Liu Fang,Han Lei,Zhang Xibing.Association between KIR Gene Polymorphism and Diabetes After Liver Transplantation[J].Theory and Practice of Science and Technology,2022,03(06):66-69. DOI: 10.47297/taposatWSP2633-456910.20220306.
One of the most frequent problems following liver transplantation is post-transplantation diabetes mellitus (PTDM)
which has a significant negative impact on the medium- and long-term quality of life of liver transplant recipients. A significant risk factor for the incidence and progression of PTDM is genetics. Killer cell immunoglobulin-like receptors (KIR) are expressed on the surface of NK cells and T cells and are members of the immunoglobulin superfamily. By identifying the appropriate ligand molecules on the surface of target cells
KIR controls the activity of NK cells and T cells. It influences Type 2 Diabetes Mellitus' (T2DM) onset and development. KIR gene polymorphism is related with T2DM
and the etiology of PTDM is comparable to that of T2DM. As a result
it may offer novel approaches to the prevention and management of diabetes following liver transplantation.
Gene polymorphismKIR genotype
Samuel D, Coilly A. Management of patients with liver diseases on the waiting list for transplantation: a major impact to the success of liver transplantation[J]. BMC Med, 2018, 16(1):113.
LING Q, XU X, WANG B, et al. The origin of newonset diabetes after liver transplantation: liver, islets, or gut?[J]. Transplantation, 2016,100 (4):808-813.
LING Q, XU X, XIE H, et al. New-onset diabetes after liver transplantation: a national report from China Liver Transplant Registry[J].Liver Int, 2016, 36(5):705-712.
SHARIF A, HECKING M, DE VRIES AP, et al. Proceedings from an international consensus meeting on posttransplantation diabetes mellitus: recommendations and future directions[J]. Am J Transplant, 2014, 14(9):1992-2000.
American Diabetes Association. Diagnosis and classification of diabetes mellitus[J]. Diabetes Care, 2014, 37(Suppl 1):S81-S90.
Boerner BP, Shivaswamy V, Wolatz E, et al. Post-transplant diabetes: diagnosis and management[J].Minerva Endocrinol,2018,43(2):198-211.
Jessica L Hwang , Roy E Weiss. Steroid-induced diabetes: a clinical and molecular approach to understanding and treatment[J].Diabetes Metab Res Rev,2014,30(2):96-102.
Sabatini PV, Speckmann T, Lynn FC. Friend and foe: β-cell Ca2+ signaling and the development of diabetes[J].Mol Metab,2019,21:1-12.
Rickels MR, Robertson RP. Pancreatic Islet Transplantation in Humans: Recent Progress and Future Directions[J].Endocr Rev,2019,40(2):631-668.
Campise M. Post-transplant diabetes mellitus: diagnosis and treatment[J].G Ital Nefrol,2007,24(6):547-557.
Zghebi SS, Rutter MK, Ashcroft DM, et al. Using electronic health records to quantify and stratify the severity of type 2 diabetes in primary care in England: rationale and cohort study design[J].BMJ Open,2018,8(6):e020926.11.
Shi FD, Zhou Q. Natural killer cells as indispensable players and therapeutic targets in autoimmunity[J].Autoimmunity,2011,44(1):3-10.
HIVASWAMY V, BOERNER B, LARSEN J. Posttransplant diabetes mellitus: causes, treatment, and impact on outcomes[J]. Endocr Rev, 2016,37(1):37-61.
Trowsdale J. Genetic and functional relationships between MHC and NK receptor genes[J].Immunity,2001,15(3):363-374.
Yu J, Heller G, Chewning J, et al. Hierarchy of the human natural killer cell response is determined by class and quantity of inhibitory receptors for self-HLA-B and HLA-C ligands[J].J Immunol,2007,179(9):5977-5989.
Fauriat C, Ivarsson MA, Ljunggren HG, et al.Education of human natural killer cells by activating killer cell immunoglobulin-like receptors[J]. Blood,2010,115(6):1166-1174.
Gagne K, Brizard G, Gueglio B, et al. Relevance of KIR gene polymorphisms in bone marrow transplantation outcome[J].Hum Immunol,2002,63(4):271-280.
Rathika Chinniah, Murali Vijayan, Ramgopal Sivanadham,et al. Diversity and association of HLA/KIR receptors with type 2 diabetes in South India[J].Int J Immunogenet,2019,46(3):166-178.
Zuniga J, Romero V, Azocar J,et al. Interaction of KIR genes and G1M immunoglobulin allotypes confer susceptibility to type 2 diabetes in Puerto Rican Americans[J].Hum Immunol,2006,67(11):907-14.
Viviana Romero, Joaquin Zúñiga, Jose Azocar,et al. Genetic interactions of KIR and G1M immunoglobulin allotypes differ in obese from non-obese individuals with type 2 diabetes[J].Mol Immunol,2008,45(14):3857-62.
Mehdi Mahmoudi, Ahmad Reza Jamshidi, Jafar Karami,et al. Analysis of Killer Cell Immunoglobulin-like Receptor Genes and Their HLA Ligands in Iranian Patients with Ankylosing Spondylitis[J].Iran J Allergy Asthma Immunol,2016,15(1):27-38.
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