6卷 第12期
1.Xi'an Medical University, Xi'an, Shaanxi, 710021, China
2.State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, National Clinical Research Center for Digestive Diseases, Xijing Hospital of Digestive Diseases, The Air Force Military Medical University, Xi'an, Shaanxi, 710032, China
纸质出版：2025-12-30
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Rui Zhang, Lina Cui, Dawei Ding & Ying Han. (2025). The Diagnostic and Prognostic Value of Transient Elastography in Primary Biliary Cholangitis. 科技理论与实践（英文版）, 6(12), 72-74.
Zhang Rui,Cui Lina,Ding Dawei,et al.The Diagnostic and Prognostic Value of Transient Elastography in Primary Biliary Cholangitis[J].Theory and Practice of Science and Technology,2025,06(12):72-74.
Rui Zhang, Lina Cui, Dawei Ding & Ying Han. (2025). The Diagnostic and Prognostic Value of Transient Elastography in Primary Biliary Cholangitis. 科技理论与实践（英文版）, 6(12), 72-74. DOI： 10.47297/taposatWSP2633-456915.20250612.
Zhang Rui,Cui Lina,Ding Dawei,et al.The Diagnostic and Prognostic Value of Transient Elastography in Primary Biliary Cholangitis[J].Theory and Practice of Science and Technology,2025,06(12):72-74. DOI： 10.47297/taposatWSP2633-456915.20250612.
Transient elastography (TE) has emerged as a pivotal noninvasive tool for assessing the liver stiffness measurement (LSM) in patients with primary biliary cholangitis (PBC). This review provides a comprehensive analysis of its diagnostic performance and its role in prognostic stratification. In terms of diagnosis
TE has demonstrated superior accuracy for staging liver fibrosis across multiple validation studies
achieving area under the receiver operating characteristic curve (AUROC) values as high as 0.99 for the detection of cirrhosis
consistently outperforming standard serological indices such as the AST-to-platelet ratio index (APRI) and the fibrosis-4 index (FIB-4). The prognostic significance of TE is profound and multifaceted. The LSM is strongly and independently correlated with the development and severity of portal hypertension and is a major driver of clinical outcomes in patients with PBC. LSM values ≥15 kPa indicate a significantly increased risk of hepatic decompensation
which is consistent with the Baveno VII consensus. In addition
the combination of TE and platelet counts can also effectively reduce unnecessary endoscopic screenings for varices.
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