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纸质出版日期： 2021 ，
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(2021). Establishment of Visual Fear Conditioning in Long－evans Rats. 生物医学大数据（英文版）, 1(1), 25-38.
(2021). Establishment of Visual Fear Conditioning in Long－evans Rats. Biomedical Data Science, 1(1), 25-38..
(2021). Establishment of Visual Fear Conditioning in Long－evans Rats. 生物医学大数据（英文版）, 1(1), 25-38. DOI： 10.47297/wspbdsWSP2752-630503.20210101.
(2021). Establishment of Visual Fear Conditioning in Long－evans Rats. Biomedical Data Science, 1(1), 25-38.. DOI： 10.47297/wspbdsWSP2752-630503.20210101.
The neural mechanisms underlying visual information transmission and coding are currently attracting the attention of neuroscience and brain－ like computing scholars. The subcortical visual pathway is known to affect fear emotion regulation via the amygdala; however an experimental para⁃ digm for visual fear cognition training remains undefined. In this study
Long －Evans (LE) rats were used to develop an experimental training paradigm for visual cognition－associated fear condi⁃ tioning based on the Pavlovian conditioning reflex. Simple imag⁃ es were shown on a unilateral screen (conditioned stimulus) were combined with electric foot shocks (unconditioned stimu⁃ lus) . We designed training paradigms and set up an estimated in-dex using the rate of successful active escape. The training results were analyzed using a two－way ANOVA
and curve fit⁃ ting was used to analyze the influence of decision time between the conditioned stimulus (CS) and unconditioned stimulus (US) on choice behavior. While neither the CS nor US had a signifi⁃cant effect on visual fear association training in LE rats
the decision time duration (CS－US) did have an impact on training. The method described here is most effec⁃ tive in establishing visual fear associations in rats when the (CS－UC) = 10 s. This study describes a new experimental training paradigm for fear conditioning using vi⁃ sual stimuli and a quantitative evaluation standard according to the training mode of visual stimula-tion graphics. Moreover
it is an efficient paradigm for future study on visual information－processing mechanisms in the sub-cortical visual pathway dur⁃ ing fear conditioning.
Fear conditioningVisual informationLong－evans ratsUnconditioned stimulusConditioningstimulus
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