Effect of Inter-follow-up HbA1c Variability on Cognitive Dysfunction In Elderly Patients with Type 2 Diabetes Mellitus

Jiaqi Hu; Linmin Gu; Ruifen Zhang

doi:10.47297/wspbdsWSP2752-630504.20240401

PDF
导出
分享
收藏
专辑

Effect of Inter-follow-up HbA1c Variability on Cognitive Dysfunction In Elderly Patients with Type 2 Diabetes Mellitus

4卷第1期

浏览量: 0 Downloads: 0

Effect of Inter-follow-up HbA1c Variability on Cognitive Dysfunction In Elderly Patients with Type 2 Diabetes Mellitus
Effect of Inter-follow-up HbA1c Variability on Cognitive Dysfunction In Elderly Patients with Type 2 Diabetes Mellitus
Department of Geriatric Psychiatry, Wuxi Mental Health Center affiliated to Jiangnan University, Wuxi 214151, China
2024年4卷第1期页码：25-29
纸质出版日期： 2024-06-30 ，
DOI：10.47297/wspbdsWSP2752-630504.20240401

Full txt

(2024). Effect of Inter-follow-up HbA1c Variability on Cognitive Dysfunction In Elderly Patients with Type 2 Diabetes Mellitus. 生物医学大数据, 4(1), 25-29.

Hu Jiaqi,Gu Linmin,Zhang Ruifen.Effect of Inter-follow-up HbA1c Variability on Cognitive Dysfunction In Elderly Patients with Type 2 Diabetes Mellitus[J].Biomedical Data Science,2024,04(01):25-29.
(2024). Effect of Inter-follow-up HbA1c Variability on Cognitive Dysfunction In Elderly Patients with Type 2 Diabetes Mellitus. 生物医学大数据, 4(1), 25-29. DOI： 10.47297/wspbdsWSP2752-630504.20240401.

Hu Jiaqi,Gu Linmin,Zhang Ruifen.Effect of Inter-follow-up HbA1c Variability on Cognitive Dysfunction In Elderly Patients with Type 2 Diabetes Mellitus[J].Biomedical Data Science,2024,04(01):25-29. DOI： 10.47297/wspbdsWSP2752-630504.20240401.

摘要

Abstract

Objective

—To evaluate the relationship between HbA1c variability and cognition impairment (CI) in patients with type 2 diabetes mellitus (T2D) and to explore the related influencing factors of CI.

Methods

—A longitudinal cohort study of 426 T2D patients was conducted

follow-up plan quarterly

a total of 2 years of follow-up to complete 8 visits. Intrapersonal mean and CV of all recorded HbA1c measurements were calculated. A1c-CV represented the measure of HbA1c variability. In addition

medical history and clinical data of all subjects were collected and analyzed.

Results

—Compared with the NCI group

patients in CI group had a longer duration of diabetes

were more likely to be complicated with coronary heart disease and stroke

diabetic nephropathy and diabetic retinopathy

and had a higher proportion of insulin use

a higher HbA1c value

a lower proportion of oral hypoglycemic agents

and a lower MMSE score (

0.05). Mixed effect results showed that A1c-Mean

A1c-SD were positively correlated with CI occurrence (β=0.037

0.033

both

0.05).

Conclusions

—HbA1c variability is an independent risk factor of CI in patients with type 2 diabetes and can be used to predict the occurrence of CI in patients with type 2 diabetes.

关键词

Keywords

Diabetes type 2HbA1c variabilityCognition impairmentInfluencing factor

references

S. Houssay,et al. Cognitive dysfunction in older adults with type 2 diabetes, IDF 2022.

Wang KL, Han S, Liu CC, et al. Correlation between blood glucose variability and mild cognitive impairment in elderly patients with type 2 diabetes[J]. Chinese medical journal, 2021, 56(7), 768-772.

Ding WH, Wang LH, Yang J, et al. Association of cognitive level with hypoglycemia and glycemic variability in type 2 diabetes mellitus[J]. Chinese Journal of Clinical Research, 2019(9):1163-1167.

Hu JQ, Hsu HC, Yuan XD, et al. HbA1c variability as an independent predictor of diabetes retinopathy in patients with type 2 diabetes. J Endocrinol Invest, 2021, 44(6):1229-1236.

Sartore G, Ragazzi E, Caprino R, Lapolla A. Long-term HbA1c variability and macro-/micro-vascular complications in type 2 diabetes mellitus: a meta-analysis update. Acta Diabetol. 2023,60(6):721-738.

Diabetes Branch of Chinese Medical Association. Chinese Guidelines for the Prevention and Treatment of Type 2 diabetes (2013 edition). Chinese Journal of Diabetes 2014, 22 (8): 2-42.

Flostein MF, Folstein SE, and McHugh PR. Mini-Mental State: a practical method for grading the cognitive state of the patients for the clinician.J Psychiatry Res. 1975, 12:196-8.

Bohlken J, Jacob L, Kostev K. Progression of mild cognitive impairment to dementia in german specialist practices[J]. Dementia. 2019; 18(1): 380-390.

Li TC, Yang CP, Tseng ST, et al. Visit-to-Visit Variations in Fasting Plasma Glucose and HbA1c Associated With an Increased Risk of Alzheimer Disease: Taiwan Diabetes Study. Diabetes Care. 2017 Sep;40(9):1210-1217.

Yu Z B , Zhu Y , Li D ,et al.Association between visit-to-visit variability of HbA 1c and cognitive decline: a pooled analysis of two prospective population-based cohorts[J].Diabetologia, 2019, 63(10113).

Lu F. Analysis of risk factors related to cognitive dysfunction in type 2 diabetic patients[D].Soochow University, 2020.

文章被引用时，请邮件提醒。

Submit

No data

Related Author

No data

Related Institution

No data

⁰