Oncolytic Virus Therapy in Solid Tumors: Clinical Translation Challenges and Strategies

Siru Chen

doi:10.47297/wspbdsWSP2752-630512.20260601

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Oncolytic Virus Therapy in Solid Tumors: Clinical Translation Challenges and Strategies

6卷第1期

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Oncolytic Virus Therapy in Solid Tumors: Clinical Translation Challenges and Strategies
Oncolytic Virus Therapy in Solid Tumors: Clinical Translation Challenges and Strategies
China Pharmaceutical University, Nanjing, Jiangsu, 211198, China
2026年6卷第1期页码：53-57
纸质出版：2026-03-30
DOI：10.47297/wspbdsWSP2752-630512.20260601
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Siru Chen. (2026). Oncolytic Virus Therapy in Solid Tumors: Clinical Translation Challenges and Strategies. 生物医学大数据, 6(1), 53-57.

Chen Siru.Oncolytic Virus Therapy in Solid Tumors: Clinical Translation Challenges and Strategies[J].Biomedical Data Science,2026,06(01):53-57.
Siru Chen. (2026). Oncolytic Virus Therapy in Solid Tumors: Clinical Translation Challenges and Strategies. 生物医学大数据, 6(1), 53-57. DOI： 10.47297/wspbdsWSP2752-630512.20260601.

Chen Siru.Oncolytic Virus Therapy in Solid Tumors: Clinical Translation Challenges and Strategies[J].Biomedical Data Science,2026,06(01):53-57. DOI： 10.47297/wspbdsWSP2752-630512.20260601.

摘要

Abstract

Oncolytic viruses (OVs)

as a type of tumor-targeted immunotherapy

show great potential in solid tumor treatment by selectively infecting and lysing tumor cells

while activating the host's anti-tumor immune response. Although products like H101 and T-VEC have been approved

their clinical translation still faces a core dilemma: feasibility of the mechanism does not equal clinical efficacy. Currently

the clinical translation of oncolytic viruses faces three major challenges. First

the preclinical-to-clinical translation dilemma

as existing animal models are unable to accurately predict the replication efficiency and immune response of the virus in the human body; second

the challenges at the clinical development stage

due to the lack of effective biomarkers to guide patient selection; and third

delivery and pharmacokinetics issues

where intratumoral injection is only suitable for superficial tumors

while systemic administration faces dual barriers from immune and physical obstacles in the tumor microenvironment. To address these challenges

the article proposes corresponding optimization strategies: first

optimizing viral vectors to enhance virus targeting and immune evasion capabilities; second

upgrading delivery systems to achieve systemic targeted delivery of the virus; and third

optimizing dosing regimens and combination therapies to induce immunogenic cell death and improve the tumor microenvironment. In the future

with advancements in precision medicine and delivery technologies

oncolytic virus therapy is expected to bring new breakthroughs in solid tumor treatment.

关键词

Keywords

references

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