Determination of Toosendanin in Different Processed Products of <italic style="font-style: italic">Toosendan Fructus</italic> by UPLC-TQD-MS/MS

Rongfan Wang; Jie Yang; Junyan Zou; Feihui Hong; Huifang Ma; Yanfang Wu; Yunli Yang; Jiamei Ma

doi:10.47297/wspbdsWSP2752-630516.20250504

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Determination of Toosendanin in Different Processed Products of <italic style="font-style: italic">Toosendan Fructus</italic> by UPLC-TQD-MS/MS

5卷第4期

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Determination of Toosendanin in Different Processed Products of Toosendan Fructus by UPLC-TQD-MS/MS
Determination of Toosendanin in Different Processed Products of Toosendan Fructus by UPLC-TQD-MS/MS
1.School of Medicine & Health Sciences, Guangzhou Huashang College, Guangzhou, Guangdong, 511300, China
2.School of Pharmacy, Guangzhou Xinhua University, Guangzhou, Guangdong, 511300, China
2025年5卷第4期页码：74-76
纸质出版：2025-12-30
DOI：10.47297/wspbdsWSP2752-630516.20250504
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Rongfan Wang, Jie Yang, Junyan Zou, Feihui Hong, Huifang Ma, Yunli Yang... & Jiamei Ma. (2025). Determination of Toosendanin in Different Processed Products of Toosendan Fructus by UPLC-TQD-MS/MS. 生物医学大数据, 5(4), 74-76.

Wang Rongfan,Yang Jie,Zou Junyan,et al.Determination of Toosendanin in Different Processed Products of Toosendan Fructus by UPLC-TQD-MS/MS[J].Biomedical Data Science,2025,05(04):74-76.
Rongfan Wang, Jie Yang, Junyan Zou, Feihui Hong, Huifang Ma, Yunli Yang... & Jiamei Ma. (2025). Determination of Toosendanin in Different Processed Products of Toosendan Fructus by UPLC-TQD-MS/MS. 生物医学大数据, 5(4), 74-76. DOI： 10.47297/wspbdsWSP2752-630516.20250504.

Wang Rongfan,Yang Jie,Zou Junyan,et al.Determination of Toosendanin in Different Processed Products of Toosendan Fructus by UPLC-TQD-MS/MS[J].Biomedical Data Science,2025,05(04):74-76. DOI： 10.47297/wspbdsWSP2752-630516.20250504.

摘要

Abstract

This study aimed to investigate the effects of various processing methods—stir-frying

salt-processing

vinegar-processing

and wine-processing—on the toosendanin content in

Toosendan Fructus

. An Ultra-Performance Liquid Chromatography-Tandem Quadrupole Mass Spectrometry (UPLC-TQD-MS/MS) method was developed. Toosendanin was extracted from both raw and processed samples and quantified using an external standard method. Results showed that all processing methods significantly reduced the toosendanin content relative to the raw sample (average: 1.124 mg/g). The reduction rates were determined as 15.2% for stir-frying

24.6% for salt-processing

41.7% for vinegar-processing

and 41.8% for wine-processing. The order of influence on content reduction was: wine-processing ≈ vinegar-processing

salt-processing

stir-frying. The established UPLC-MS/MS method is suitable for the quantitative analysis of toosendanin. Processing significantly reduces toosendanin content

with vinegar- and wine-processing showing the most pronounced effects. These findings provide essential data for optimizing processing protocols and quality control standards

thereby supporting the safer clinical use of

Toosendan Fructus

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Keywords

references

Chinese Pharmacopoeia Commission . Pharmacopoeia of the People's Republic of China [S ] . 2025 ed. Vol 1. Beijing : China Medical Science Press , 2025 : 45 .

Chang H , Wang C , Gong LL , et al . An overview of Fructus Meliae Toosendan : botany, traditional uses, phytochemistry, pharmacology and toxicology [J ] . Biomed Pharmacother , 2023 , 157 : 113795 .

Li HB , Ma SJ , Shi DF , et al . Research progress on chemical constituents, pharmacological action and toxicity of Melia toosendan [J ] . Chin Tradit Herb Drugs , 2020 , 51 : 4059 - 4074 .

Xu L , Huang QY , Yang DM . Research progress in hepatotoxicity of toxic traditional Chinese medicines in 2025 edition of Pharmacopoeia of the People′s Republic of China [J ] . Chin J Pharmacol Toxicol , 2025 , 39 ( 9 ): 689 - 702 .

Qin CC , Du QY , Zhang YM , et al . Historical evolution of processing and modern research progress of Toosendan Fructus [J ] . Chinese Traditional Patent Medicine , 2023 , 45 ( 05 ): 1603 - 1609 .

Zeng CH , Xing LR , Chen HP , et al . Principles Of Processing Method Reducing Hepatotoxicity Of Chuanlianzi ( Toosendan Fructus ): Bioinformatics Prediction And Experiment Validation [J ] . Chinese Archives of Traditional Chinese Medicine , 2025 , 43 ( 4 ): 1 - 6 .

Huang YM , Zhang ZL , Dong K , et al . Determination of toosendanin in Toosendan Fructus by HPLC-CAD couple d with solid phase extraction [J ] . Acta Pharmaceutica Sinica 2025 , 60 ( 9 ): 2876 - 2882 .

Liang ZR , Wu SQ . Determination of Toosendanin in Toosendan Fructus by UPLC-MS/MS [J ] . Guangdong Chemical Industry , 2023 , 50 ( 20 ): 155 - 156 .

Li ZN , Fan Y , Li ZH , et al . Method for the Determination of Toosendanin in Medicinal Materials Based on UPLC-MS/MS Technology [J ] . Henan Science , 2017 , 35 ( 9 ): 1406 - 1411 .

Li S , Xiong Q , Shen Y , Lin J , Zhang L , Wu Y , Jin J , Luan X . Toosendanin: upgrade of an old agent in cancer treatment [J ] . Chin J Nat Med . 2024 , 22 ( 10 ): 887 - 899 .

Zhang Q , Xue R , Xu RJ , He TY , Su LL , Zhang W , Li L , Ji D , Mao CQ , Lu TL . Processing theory of "leading vinegar-processing Chinese medicine into liver " [J ] . Zhongguo Zhong Yao Za Zhi . 2022 , 47 ( 18 ): 4854 - 4862 .

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Determination of Toosendanin in Different Processed Products of Toosendan Fructus by UPLC-TQD-MS/MS

Determination of Toosendanin in Different Processed Products of Toosendan Fructus by UPLC-TQD-MS/MS

DOI：10.47297/wspbdsWSP2752-630516.20250504

摘要

Abstract

关键词

Keywords

references