Research Progress of Extracellular Trapping Nets and Pancreatic Cancer

Hongji Hua; Yi Liu

doi:10.47297/wspbdsWSP2752-630520.20260601

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Research Progress of Extracellular Trapping Nets and Pancreatic Cancer

6卷第1期

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Research Progress of Extracellular Trapping Nets and Pancreatic Cancer
Research Progress of Extracellular Trapping Nets and Pancreatic Cancer
Hunan Provincial People's Hospital, Changsha, Hunan, 410000, China
2026年6卷第1期页码：90-93
纸质出版：2026-03-30
DOI：10.47297/wspbdsWSP2752-630520.20260601
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Hongji Hua & Yi Liu. (2026). Research Progress of Extracellular Trapping Nets and Pancreatic Cancer. 生物医学大数据, 6(1), 90-93.

Hua Hongji,Liu Yi.Research Progress of Extracellular Trapping Nets and Pancreatic Cancer[J].Biomedical Data Science,2026,06(01):90-93.
Hongji Hua & Yi Liu. (2026). Research Progress of Extracellular Trapping Nets and Pancreatic Cancer. 生物医学大数据, 6(1), 90-93. DOI： 10.47297/wspbdsWSP2752-630520.20260601.

Hua Hongji,Liu Yi.Research Progress of Extracellular Trapping Nets and Pancreatic Cancer[J].Biomedical Data Science,2026,06(01):90-93. DOI： 10.47297/wspbdsWSP2752-630520.20260601.

摘要

Abstract

Neutrophil extracellular trapping NETs (NETs) are a special mode of cell death. More and more studies have shown that NETs are involved in the pathophysiological processes of various disease formation

inflammation

tumors and other diseases. Pancreatic cancer is one of the most malignant tumors found at present

and due to its occult onset

it is difficult to make early diagnosis of pancreatic cancer patients

and its 5-year overall survival rate is only about 10%. At present

the incidence of pancreatic cancer is still increasing

and it has become one of the important factors threatening human life and health. Current studies have shown that NETs are an important factor involved in the proliferation

metastasis

chemoresistance of pancreatic cancer cells and the formation of venous thrombosis in pancreatic cancer patients. The author reviews this.

关键词

Keywords

references

Fousert E , Toes R , Desai J . Neutrophil extracellular traps (NETs) take the central stage in driving autoimmune responses [J/O L ] . Cells , 2020 , 9 ( 4 ): 915 .

BRINKMANN V , REICHARD U , GOOSMANN C , et al . Neutrophil extracellular traps kill bacteria [J ] . Science (New York, NY) , 2004 , 303 ( 5663 ): 1532 - 5 .

de Bont C M , Koopman W , Boelens W C , et al . Stimulus-dependent chromatin dynamics, citrullination, calcium signalling and ROS production during NET formation [J/O L ] . Biochim Biophys Acta Mol CeU R es , 2 0 1 8 , 1865 ( 11 Pt A): 1621-1629.

Volkman R , Ben-Zur T , Kahana A , et al . Myeloperoxidase deficiency inhibits cognitive decline in the 5XFAD mouse model of Alzheimer's disease [J/O L ] . Front Neurosci , 20 1 9 , 13 : 990 . DOI: 10.3389/fnins. 2019. 00990. eCoUection 2019 http://dx.doi.org/10.3389/fnins.2019.00990.eCoUection2019 .

Manfredi A A , Ramirez G A , Rovere-Querini P , et al . The neutrophil's choice: Phagocytose vs make neutrophil extracellular traps [J/O L ] . Front Immunol , 20 1 8 , 9 : 288 .

Amulic B , Knackstedt S L , Abu Abed U , et al . Cell-cycle proteins control production of neutrophil extracellular traps [J/OL ] . Dev CeU , 20 1 7, 43 ( 4 ): 449 - 462 . e 5 .

Bravo-Barrera J , Kourilovitch M , Galarza-Maldonado C . Neutrophil extracellular traps, antiphospholipid antibodies and treatment [J/O L ] . Antibodies (B a sel) , 2 0 1 7 , 6 ( 1 ): E4 .

Ravindran M , Khan M A , Palaniyar N . Neutrophil extracellular trap formation: Physiology, pathology, and pharmacology [J/O L ] . Biomolecules , 2 0 1 9 , 9 ( 8 ): E365 .

E ^ ibalzadeh K , Geoip L , Louis T , et al . Compromised anti-inflammatory action of neutrophil extracellular traps in PAD4-deficient mice contributes to aggravated acute inflammation after myocardial infarction . Front Immunol , 2 0 1 9 , 10 : 2313 .

Holmes C L , Shim D , Kemien J , et al . Insight into neutrophil extracellular traps through systematic evaluation of citrullination and peptidylai ^ inine deiminases [J/O L ] . J Immunol R es , 20 1 9 , 20 1 9 : 2160192 .

Stoiber W , Obermayer A , Steinbacher P , et al . The role of reactive oxygen species (ROS) in the formation of extracellular traps (E T s) in h u m ans [J ] . Biomolecules , 20 1 5 , 5 ( 2 ): 702 - 7 2 3 .

Galkina S I , Fedorova N V , Golenkina E A , et al Cytonemes versus neutrophil extracellular traps in the fight of neutrophils with microbes [J/O L ] . Int J Mol S ci , 20 2 0 , 21 ( 2 ): 586 .

Teijeira Á , Garasa S , Gato M , et al . CXCR1 and CXCR2 Chemokine Receptor Agonists Produced by Tumors Induce Neutrophil Extracellular Traps that Interfere with Immune Cytotoxicity [J ] . Immunity , 2020 , 52 ( 5 ): 856 - 871 .

Miller-Ocuin JL , Liang X , Boone BA , et al . DNA released from neutrophil extracellular traps (NETs) activates pancreatic stellate cells and enhances pancreatic tumor growth [J ] . Oncoimmunology , 2019 , 8 ( 9 ): e1605822 .

Cools-Lartigue J , Spicer J , Najmeh S , et al . Neutrophil extracellular traps in cancer progress [J ] . Cell Mol Life Sci , 2014 , 71 ( 21 ): 4179 - 4194 .

Spicer JD , McDonald B , Cools-Lartigue JJ , et al . Neutrophils promote liver metastasis via Mac-1-mediated interactions with circulating tumor cells [J ] . Cancer Res , 2012 , 72 ( 16 ): 3919 - 3927 .

Cools-Lartigue J , Spicer J , McDonald B , et al . Neutrophil extracellular traps sequester circulating tumor cells and promote metastasis [J ] . J Clin Invest , 2013 , 123 ( 8 ): 3446 - 3458 .

McAllister SS , Weinberg RA . The tumour-induced systemic environment as a critical regulator of cancer progression and metastasis [J ] . Nat Cell Biol , 2014 , 16 ( 8 ): 717 - 727 .

Malanchi I , Santamaria-Martínez A , Susanto E , et al . Interactions between cancer stem cells and their niche government metastatic colonization [J ] . Nature , 2011 , 481 ( 7379 ): 85 - 89 .

Quail DF , Joyce JA . Microenvironmental regulation of tumor progress and metastasis [J ] . Nat Med , 2013 , 19 ( 11 ): 1423 - 1437 .

Erler JT , Bennewith KL , Cox TR , et al . Hypoxia-induced lysyl oxidase is a crit-ical mediator of bone marrow cell recruitment to form the premetastatic niche [J ] . Cancer Cell , 2009 , 15 ( 1 ): 35 - 44 .

Takesue S , Ohuchida K , Shinkawa T , et al . Neutrophil extracellular traps promotes liver micrometastasis in pancreatic ductal adenocarcinoma via the activation of cancer associated fibroblasts [J ] . Int J Oncol , 2020 , 56 ( 2 ): 596 - 605 .

HOUGHTON A M , RZYMKIEWICZ D M , JI H , et al . Neutrophil elastasemediated degradation of IRS-1 accelerates lung tumor growth [J ] . Nat Med , 2010 , 16 ( 2 ): 219 - 23 .

Jin Lin . KDM6A deletion promotes TANs infiltration and NETs formation in pancreatic cancer through the CXCL1-CXCR2 axis [D ] . Tutor : Yu Zhang; Vermilion. Central South University , 2022 .

Timp JF , Braekkan SK , Versteeg HH , et al . Epidemiology of cancerassociated venous thrombosis [J ] . Blood , 2013 , 122 ( 10 ): 1712 - 1723 .

Jung HS , Gu J , Kim JE , et al . Cancer cell-induced neutrophil extracellular traps promotes both hypercoagulability and cancer progress [J ] . PLoS One , 2019 , 14 ( 4 ): e0216055 .

Brill A , Fuchs TA , Savchenko AS , et al . Neutrophil extracellular traps promotes deep vein thrombosis in mice [J ] . J Thromb Haemost , 2012 , 10 ( 1 ): 136 - 144 .

Fuchs TA , Brill A , Wagner DD . Neutrophil extracellular trap (NET) impact on deep vein thrombosis [J ] . Arterioscler Thromb Vasc Biol , 2012 , 32 ( 8 ): 1777 - 1783 .

Noubouossie DF , Reeves BN , Strahl BD , et al . Neutrophils: back in the thrombosis spotlight [J ] . Blood , 2019 , 133 ( 20 ): 2186 - 2197 .

Hisada Y , Grover SP , Maqsood A , et al . Neutrophils and neutrophil extracellular traps enhance venous thrombosis in mice bearing human pancreatic tumors [J ] . Haematologica , 2020 , 105 ( 1 ): 218 - 225 .

Neutrophil Extracellular Traps Confer Chemoresistance through TGFβ . [J ] . Cancer discovery , 2023 , 13 ( 7 ).

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