6卷 第1期
Wuhan Business University, Wuhan, Hubei, 430056, China
纸质出版：2026-03-30
Scan QR Code
Jingcheng Li. (2026). Applications of Structural Saccharides in Disease Therapy. 生物医学大数据, 6(1), 106-111.
Li Jingcheng.Applications of Structural Saccharides in Disease Therapy[J].Biomedical Data Science,2026,06(01):106-111.
Jingcheng Li. (2026). Applications of Structural Saccharides in Disease Therapy. 生物医学大数据, 6(1), 106-111. DOI： 10.47297/wspbdsWSP2752-630524.20260601.
Li Jingcheng.Applications of Structural Saccharides in Disease Therapy[J].Biomedical Data Science,2026,06(01):106-111. DOI： 10.47297/wspbdsWSP2752-630524.20260601.
Structural sugars are a class of natural or modified carbohydrates with wide sources and diverse structures
mainly including polysaccharides
glycosides
glycoconjugates
and glycomimetics. Their biological activities are often Under the influence of factors including molecular weight
monosaccharide composition
and glycosidic linkage patterns. In recent years
with the advancement of glycobiology
the therapeutic potential of these compounds against various diseases has been gradually explored. This paper reviews the applications of structural sugars in the medical field
summarizes their major types and physicochemical properties
and discusses their mechanisms of action in disease intervention. Furthermore
the research progress in the treatment of tumors
inflammatory diseases and other disorders is analyzed with typical examples. The current technical bottlenecks and challenges in related studies are also addressed
and the future design strategies and translational directions of structural sugar-based drugs are prospected. This review aims to provide a reference for further investigations and clinical applications.
LIN Y H , SUN B N , JIN Z , et al . Enhanced immune responses to mucosa by functionalized chitosan-based composite nanoparticles as a vaccine adjuvant for intranasal delivery [J ] . ACS Applied Materials & Interfaces , 2022 , 14 ( 47 ): 52691 - 52701 .
MOHAMED N A , FAHMY M M . Synthesis and antimicrobial activity of some novel cross-linked chitosan hydrogels [J ] . International Journal of Molecular Sciences , 2012 , 13 ( 9 ): 11194 - 11209 .
GAO Y , GONG X C , YU S , et al . Immune enhancement of N-2- hydroxypropyl trimethyl ammonium chloride chitosan/carboxymethyl chitosan nanoparticles vaccine [J ] . International Journal of Biological Macromolecules , 2022 , 220 : 183 - 192 .
NAGPAL K , SINGH S K , MISHRA D N . Chitosan nanoparticles: a promising system in novel drug delivery [J ] . Chemical and Pharmaceutical Bulletin , 2010 , 58 ( 11 ): 1423 - 1430 .
JIAN N , HU J Y , ZHANG R , et al . Research progress in preparation of chitosan composite adsorbent [J ] . Liaoning Chemical Industry , 2023 , 52 ( 2 ): 259 - 261, 268 .
XIE L Y , KE J Z , CHEN Y , et al . The research progress of preparation of chitosan nanoparticles and its application in the targeted drug delivery system [J ] . China Licensed Pharmacist , 2013 , 10 ( 4 ): 34 - 38 .
WU J , CHEN Q , WANG W F , et al . Chitosan derivative-based microspheres loaded with fibroblast growth factor for the treatment of diabetes [J ] . Polymers , 2023 , 15 ( 14 ): 3099 .
ZHAO Z , HAN J Y , XU S G , et al . Amoxicillin encapsulated in the N-2-hydroxypropyl trimethyl ammonium chloride chitosan and N, O-carboxymethyl chitosan nanoparticles:preparation, characterization,and antibacterial activity [J ] . International Journal of Biological Macromolecules , 2022 , 221 : 613 - 622 .
MA Q M , JIN Y Q , CAO J , et al . Recent progress of self-assembly-based chitosan/phospholipid nanoparticles for advanced drug delivery [J ] . Chinese Journal of Pharmaceuticals , 2021 , 52 ( 5 ): 619 - 627 .
CHU X Y , HUANG W , WANG Y L , et al . Improving antitumor outcomes for palliative intratumoral injection therapy through lecithin–chitosan nanoparticles loading paclitaxel–cholesterol complex [J ] . International Journal of Nanomedicine , 2019 , 14 : 689 - 705 .
Wen Tang , Huiwen Hou , Hanlin Wang , Xinqing Gao , Feiyan Zhao , Yuhan Di , Shengli Ji , Peixue Ling , Fengshan Wang , Feng Sun , and Haining Tan . ACS Applied Materials & Interfaces 2024 16 ( 34 ), 44409 - 44427 .
Dekker E , Tanis P J , Vleugels J L A , et al . Colorectal cancer [J ] . Lancet , 2019 , 394 ( 10207 ): 1467 - 1480 .
Kumar C S , Thangamr R , Mary S A , et al . Targeted delivery and apoptosis induction of trans-resveratrol-ferulic acid loaded chitosan coated folic acid conjugate solid lipid nanoparticles in colon cancer cells [J ] . Carbohydr Polym , 2020 , 231 : 115682 .
Dramou P , Fizir M , Taleb A , et al . Folic acid-conjugated chitosan oligosaccharide-magnetic halloysite nanotubes as a delivery system for camptothecin [J ] . Carbohydr Polym , 2018 , 197 : 117 - 127 .
Zhang Y . Y . ( 2025 ). Construction and anti-tumor properties of functionalized chitosan/polydopamine nanomedicine [Doctoral dissertation ] . Donghua University , Shanghai, China .
LIU L Y , ZHOU C P , XIA X J , et al . Self-assembled lecithin/ chitosan nanoparticles for oral insulin delivery: preparation and functional evaluation [J ] . International Journal of Nanomedicine , 2016 , 11 : 761 - 769 .
SENYIGIT T , SONVICO F , ROSSI A , et al . In vivo assessment of clobetasol propionate-loaded lecithin-chitosan nanoparticles for skin delivery [J ] . International Journal of Molecular Sciences , 2016 , 18 ( 1 ): 32 .
Lv S . ( 2025 ). Effects of glucose, mannooligosaccharide and lentinan alone and in combination with docetaxel on mammary tumor in mice [Master's thesis]. Shenyang Agricultural University, Shenyang, China .
Wei MM , Wang YS , Ye XS . Carbohydrate-based vaccines for oncotherapy [J ] . Med Res Rev , 2018 , 38 : 1003 - 1026 .
Fu JJ , Yang JX , Seeberger PH , et al . Glycoconjugates for glucose transporter-mediated cancer-specific targeting and treatment [J ] . Carbohydr Res , 2020 , 498 : 108195 .
Liu Y , Li BH , Zheng XJ , et al . Cancer vaccines based on fluorine-modified KH-1 elicit robust immune response [J ] . Molecules , 2023 , 28 : 1934 .
Huo CX , Ye XS . Recent advance in carbohydrate-based cancer vaccines [J ] . Acta Pharm Sin (药学学报) , 2012 , 47 : 261 - 270 .
Huan Yu , Yang Yang , Tianyan Jiang , Xihui Zhang , Yuhao Zhao , Guibin Pang , Yahui Feng , Shulei Zhang , Fujun Wang , Yong Wang , Yangyun Wang , and Leshuai W . Zhang . ACS Applied Materials & Interfaces 2019 11 ( 31 ), 27536 - 27547 .
Yang B Q , Liu G R , Shao Y S , et al . Atractylodes macrocephala polysaccharide induces apoptosis of human endometrial cancer RL95-2 cells by regulating the mitochondrial apoptotic pathway [J ] . Chinese Journal of Immunology , 2022 , 38 ( 12 ): 1458 - 1462 .
Zhang Z M , Pang L . Effects of trametes robiniophila polysaccharide on the biological behavior of endometrial cancer cells by inhibiting AEG-1 expression [J ] . Journal of North Sichuan Medical College , 2023 , 38 ( 10 ): 1299 - 1305 .
Zhang Y. G. , Yan X. F. , Liu Y. , Liu L. L. , Liu F. , Hao W. Z. , Cai Y. , & Li X . J . ( 2024 ). Astragalus polysaccharides induces ferroptosis in ovarian cancer cells through the Nrf2/SLC7A11/GPX4 signaling pathway. Chinese Journal of Chinese Materia Medica , 49 ( 23 ), 5646 - 5654 .
Wang H. J. , Hu Z. M. , Yu X. T. , Chen Z. J. , Wu T. X. , Fan J. Y. , Wang W. Y. , Zhang L. Q. , Liu X. Y. , & Lu Y . ( 2026 ). Ginseng polysaccharide-chitosan oligosaccharide nanoparticles combined with radiotherapy promote NK cells differentiation and enhance antitumor efficacy via IFN-I-mediated JAK3/STAT5 pathway . Chinese Traditional and Herbal Drugs , 57 ( 2 ), 541 - 552 .
Zhao M . T . ( 2025 ). The impact of degree of polymerization on the inhibition of LPS-induced inflammation in RAW264.7 by chitooligosaccharides [Master's thesis ] . Guangxi University , Nanning, China .
Wang B. , Zhao Y. K. , Jiang Q. X. , Xu Y. S. , & Xia W . S . ( 2024 ). Protective effect of chitosan oligosaccharide on ethanol-induced inflammatory reaction. Journal of Chinese Institute of Food Science and Technology , 24 ( 8 ), 216 - 224 .
Xu D. F. , Wang Y. , Xia Y. F. , Wu L. L. , Zhu K. Y. , Du R. , & Sun J . C . ( 2025 ). Effects of Polygonatum sibiricum polysaccharides on high-sugar diet-induced neuroinflammation in mice. Chinese Journal of Pathophysiology , 41 ( 7 ), 1275 - 1288 .
Related Author
Related Institution
京公网安备11010802024621