Recent Advances in Prodrug Design: Chemical Strategies and Pharmaceutical Applications

Liying Chen

doi:10.47297/wspbdsWSP2752-630523.20250503

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Recent Advances in Prodrug Design: Chemical Strategies and Pharmaceutical Applications

Volume 5, Issue 3

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Recent Advances in Prodrug Design: Chemical Strategies and Pharmaceutical Applications
Recent Advances in Prodrug Design: Chemical Strategies and Pharmaceutical Applications
University of South China, Hengyang, Hunan, 421001, China
Vol. 5, Issue 3, Pages: 115-118(2025)
Published：30 September 2025
DOI：10.47297/wspbdsWSP2752-630523.20250503
Accepted：

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Chen Liying.Recent Advances in Prodrug Design: Chemical Strategies and Pharmaceutical Applications[J].Biomedical Data Science,2025,05(03):115-118.
DOI：

Chen Liying.Recent Advances in Prodrug Design: Chemical Strategies and Pharmaceutical Applications[J].Biomedical Data Science,2025,05(03):115-118. DOI： 10.47297/wspbdsWSP2752-630523.20250503.

摘要

Abstract

As a crucial molecular modification strategy

prodrugs enable the release of active pharmaceutical ingredients through enzymatic or chemical reactions within the body

thereby playing a pivotal role in enhancing drug solubility

stability

bioavailability

and safety. With advances in medicinal chemistry

nanotechnology

and biomedicine

prodrug research has expanded beyond mere physicochemical optimization to encompass targeted therapy and personalized medicine. This paper systematically reviews the fundamental principles

classification

primary applications

development challenges

and future directions of prodrugs. It highlights emerging trends such as drug-auxiliary prodrugs

microenvironment-responsive prodrugs

AI-assisted design

and enzyme-mediated prodrug therapies.

关键词

Keywords

references

Kim CG , Jose J , Hay MP , Choi PJ . Novel prodrug strategies for treating tuberculosis . The Journal of Asia 2024 Dec 2 ; 19 ( 23 ): e202400944 .

Sui, D., Song, Y., & Deng, Y. Lipid-based prodrug liposomes remodel disease-associated neutrophils to promote cancer immune cycling . Journal of Nanobiotechnology 23 , 132 ( 2025 ).

Takagi T. ; Ramachandran C. ; Bermellho M. ; Yamashita S. ; Yu , LX ; Amiton , GL . Provisional biopharmaceutical classification of the top 200 oral drug products in the US, UK, Spain, and Japan . Pharmacist . 2006 , 3 , 631 – 643 .

Verbeeck RK , Kanfer I , Löbenberg R , Abrahamsson B , Cristofoletti R , Groot DW , Langguth P , Polli JE , Parr A , Shah VP , Mehta M , Dressman JB . Bioequivalence monograph of immediate-release solid oral dosage forms: enalapril . Journal of Pharmacy. August 2017 ; 106 ( 8 ): 1933 - 1943 .

Shen H , Zhang C , Li S , Liang Y , Li LT , Agarwal N , Wu KS , Liu J , Nadarajan SP , Weng C , Ling H , Tai JK , Wang Y , Yao SQ , Huang IY , Li YS , Zhang MW . Prodrug-conjugated tumor-targeting symbionts for targeted cancer therapy . Nat Commun . 2024 May 21 ; 15 ( 1 ): 4343 .

Chien ST , Suydam IT , Woodrow KA . Prodrug approaches for developing sustained-release drug delivery systems . Adv Drug Deliv Rev . 2023 Jul ; 198 : 114860 .

Xie A , Hanif S , Ouyang J , Tang Z , Kong N , Kim NY , Qi B , Patel D , Shi B , Tao W . Stimulus-responsive prodrug cancer nanomedicine . EBioMedicine. June 2020 ; 56 : 102821 .

Mehellou Y , Rattan HS , Balzarini J . ProTide prodrug technology: from concept to clinical application . J Med Chem . 2018 Mar 22 ; 61 ( 6 ): 2211 - 2226 .

Cao Y , Ge X , Zhu X , Han Y , Wang P , Akakuru OU , Wu A , Li J . Tumor microenvironment-responsive convertible neuropeptide prodrug inhibits triple-negative breast cancer tumor growth and metastasis . Advanced Science (Weinh). July 2023 ; 10 ( 21 ): e2300545 .

Breijyeh Z , Karaman R . Enzyme-like models—from catalysis to prodrugs . Molecules . 2021 May 28 ; 26 ( 11 ): 3248 .

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